{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T15:22:38Z","timestamp":1782314558520,"version":"3.54.5"},"reference-count":56,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Preeclampsia is associated with adverse maternal and neonatal outcomes. It is unclear whether multivitamin use reduces the risk of preeclampsia. This systematic review and meta\u2010analysis aimed to evaluate the association between multivitamin use and the risk of preeclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>We searched PubMed, Embase and the Cochrane Library from database inception to July 2021. Randomized controlled trials (RCTs), case\u2013control and cohort studies assessing the association between multivitamin use and risk of preeclampsia were eligible. Studies of treatment with a single micronutrient were excluded. Relative risks and 95% confidence intervals (95% CI) were calculated using random\u2010effects models. RoB2, the Newcastle Ottawa Scale and GRADE were used to assess risk of bias and quality of evidence. The protocol was registered in PROSPERO (no. CRD42021214153).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six studies were included (33\u2009356 women). Only two RCTs were found, both showing a significantly decreased risk of preeclampsia in multivitamin users. These studies were not compatible for meta\u2010analysis due to clinical heterogeneity. A meta\u2010analysis of observational studies using a random\u2010effects model showed an unchanged risk of preeclampsia following multivitamin use (relative risk 0.85, 95% CI 0.69\u20131.03). The quality of evidence according to GRADE was very low.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Very weak evidence suggests that multivitamin use might reduce the risk of preeclampsia; however, more research is needed. Large RCTs should be prioritized. The results of this review do not allow any final conclusions to be drawn regarding a preventive effect of multivitamin use in relation to preeclampsia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14356","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T08:23:53Z","timestamp":1649319833000},"page":"1038-1047","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Multivitamin use and risk of preeclampsia: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1802-6554","authenticated-orcid":false,"given":"Cecilie Holm","family":"Christiansen","sequence":"first","affiliation":[{"name":"The Interdisciplinary Research Unit of Women\u2019s Children\u2019s and Families\u2019 Health, Rigshospitalet Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8712-1088","authenticated-orcid":false,"given":"Stinne","family":"H\u00f8gh","sequence":"additional","affiliation":[{"name":"The Interdisciplinary Research Unit of Women\u2019s Children\u2019s and Families\u2019 Health, Rigshospitalet Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Department of Obstetrics Juliane Marie Center, Rigshospitalet Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line","family":"Rode","sequence":"additional","affiliation":[{"name":"Department of Clinical biochemistry Copenhagen University Hospital Glostrup  Glostrup Denmark"},{"name":"Center of Fetal Medicine and Pregnancy Department of Obstetrics, Rigshospitalet Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1776-0562","authenticated-orcid":false,"given":"Jeppe Bennekou","family":"Schroll","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Copenhagen University Hospital, Hvidovre Hospital  Hvidovre Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne Kristine","family":"Hegaard","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Juliane Marie Center, Rigshospitalet Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4598-9938","authenticated-orcid":false,"given":"Hanne Trap","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Copenhagen University Hospital, Hvidovre Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.05.005"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2008.09.014"},{"key":"e_1_2_10_4_1","unstructured":"World Health OrganizationInternational Classification of Diseases and Related Health Problems 10th Revision. 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