{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:02:29Z","timestamp":1792004549837,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014197","name":"Stiftelsen Mary von Sydows, f\u00f6dd Wijk, donationsfond","doi-asserted-by":"publisher","award":["2019\u20102219"],"award-info":[{"award-number":["2019\u20102219"]}],"id":[{"id":"10.13039\/501100014197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003745","name":"Stiftelserna Wilhelm och Martina Lundgrens","doi-asserted-by":"publisher","award":["2019\u20102941"],"award-info":[{"award-number":["2019\u20102941"]}],"id":[{"id":"10.13039\/501100003745","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2022,8]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n Magnesium sulfate is used world\u2010wide to treat pregnant women at imminent risk of preterm delivery in order to protect the brain of the premature infant. Previous research has shown that magnesium sulfate decreases the risk of cerebral palsy by ~30% in infants born preterm. Despite this, the dosage required for optimal neuroprotection remains unknown. We aimed to investigate whether 6 g magnesium sulfate given as a single bolus dose was tolerable for the women and infants and whether the desired target concentration in the mother's blood was reached and non\u2010toxic level in the infant could be ensured.<\/jats:p>\n <\/jats:sec>\n \n Material and methods<\/jats:title>\n In total, 49 women who were at risk of delivery prior to 32\u2009weeks of gestation were recruited. They received a bolus dose of 6 g magnesium sulfate intravenously between 1 and 24\u00a0h prior to giving birth and were closely monitored during and after infusion. Blood samples from the patients were analyzed at different time\u2010points (20\u201330\u00a0min after start of infusion, 1, 2, 6 and 24\u00a0h) post\u2010administration. Blood samples from the umbilical cord were also taken directly after birth to assess the concentration of magnesium in the infant.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n None of the women who received magnesium sulfate reached serum magnesium concentrations >3.3\u2009mmol\/L. In all, 72% of the women showed serum magnesium levels within the therapeutic interval (2.0\u20133.5\u2009mmol\/L) and no adverse events were observed during the infusion. The serum magnesium levels in the mothers declined to pre\u2010bolus\u2010levels within 24\u00a0h after delivery. Serum magnesium levels in the umbilical cord samples ranged from 0.87 to 1.4\u2009mmol\/L, which means that all but two were within the normal expected range for a newborn premature infant.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n A bolus dose of 6 g magnesium sulfate was well tolerated and without any serious side effects in either mother or infant. Most of our women reached the targeted concentration range of serum magnesium levels after infusion was completed. Their infants had magnesium levels within acceptable levels, regardless of gestational week or mother's body mass index.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/aogs.14372","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T00:28:10Z","timestamp":1651537690000},"page":"856-861","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Maternal and fetal serum concentrations of magnesium after administration of a 6\u2010g bolus dose of magnesium sulfate (\n \n MgSO\n 4<\/sub>\n <\/scp>\n ) to women with imminent preterm delivery"],"prefix":"10.1111","volume":"101","author":[{"given":"Andrea","family":"Jonsdotter","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Region V\u00e4stra G\u00f6taland Sahlgrenska University Hospital Gothenburg Sweden"},{"name":"Center of Perinatal Medicine and Health Institute of Clinical Sciences Sahlgrenska Academy, University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eridan","family":"Rocha\u2010Ferreira","sequence":"additional","affiliation":[{"name":"Center of Perinatal Medicine and Health Institute of Clinical Sciences Sahlgrenska Academy, University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Hagberg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Region V\u00e4stra G\u00f6taland Sahlgrenska University Hospital Gothenburg Sweden"},{"name":"Center of Perinatal Medicine and Health Institute of Clinical Sciences Sahlgrenska Academy, University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1414-7279","authenticated-orcid":false,"given":"Ylva","family":"Carlsson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Region V\u00e4stra G\u00f6taland Sahlgrenska University Hospital Gothenburg Sweden"},{"name":"Center of Perinatal Medicine and Health Institute of Clinical Sciences Sahlgrenska Academy, University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2002.019752"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60820-4"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60136-1"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2008.02047.x"},{"key":"e_1_2_11_6_1","unstructured":"WHO fact sheets about preterm 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