{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T02:56:58Z","timestamp":1782356218081,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Minimally invasive methods to reduce menorrhagia were introduced in the 1980s and 1990s. Transcervical endometrial resection (TCRE) and endometrial ablation (EA) are two of the most frequently used methods. As none of them can guarantee a complete removal of the endometrium, there are concerns that the remaining endometrium may develop to endometrial cancer (EC) later in life. The primary aim was to analyze the long\u2010term incidence of EC after TCRE and EA in a nationwide population. The secondary aim was to assess the two treatment modalities separately.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>The Swedish National Patient Registry and National Quality Registry for Gynecological Surgery were used for identification of women who had TCRE or EA performed between 1997\u20132017. The cohort was followed from the first TCRE or EA until hysterectomy, diagnosis of EC, or death. Follow\u2010up data were retrieved from the National Cancer Registry and the National Death Registry. Expected incidence for EC in Swedish women was calculated using Swedish data retrieved from the NORDCAN project after having taken into account differences of age and follow\u2010up time. Cumulative incidence of EC after TCRE and EA, was calculated. A standardized incidence ratio was calculated based on the expected and observed incidence, stratified by age and year of diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 17\u2009296 women (mean age 45.1\u2009years) underwent TCRE (<jats:italic>n<\/jats:italic>\u00a0=\u00a08626) or EA (<jats:italic>n<\/jats:italic>\u00a0=\u00a08670). Excluded were 3121 who had a hysterectomy for benign causes during follow up. During a median follow\u2010up time of 7.1\u2009years (interquartile range 3.1\u201313.3\u2009years) the numbers of EC were 25 (0.3%) after TCRE and 2 (0.02%) after EA, respectively. The observed incidence was significantly lower than expected (population\u2010based estimate) after EA but not after TCRE, giving a standardized incidence ratio of 0.13 (95% confidence interval [CI] 0.03\u20130.53) after EA and 1.27 (95% CI 0.86\u20131.88) after TCRE. Median times to EC were 3.0 and 8.3\u2009years after TCRE and EA, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was a significant reduction of EC after EA, suggesting a protective effect, whereas endometrial resection showed an incidence within the expected rate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14385","type":"journal-article","created":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T04:36:04Z","timestamp":1653712564000},"page":"923-930","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Long\u2010term incidence of endometrial cancer after endometrial resection and ablation: A population based Swedish gynecologic cancer group (<scp>SweGCG<\/scp>) study"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1068-9732","authenticated-orcid":false,"given":"Angelique","family":"Fl\u00f6ter R\u00e5destad","sequence":"first","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Division of Neonatology, Obstetrics and Gynecology, Karolinska Institutet Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4678-1757","authenticated-orcid":false,"given":"Pernilla","family":"Dahm\u2010K\u00e4hler","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Institute of Clinical Sciences, Sahlgrenska Academy  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Holmberg","sequence":"additional","affiliation":[{"name":"Department of Oncology, Institute of Clinical Sciences Sahlgrenska Academy, University of Gothenburg, and Region V\u00e4stra G\u00f6taland, Regional Cancer Center West  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Bjurberg","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Radiation Physics Sk\u00e5ne University Hospital  Lund Sweden"},{"name":"Department of Clinical Sciences Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Hellman","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Cancer, Theme Cancer Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"H\u00f6gberg","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Institute of Clinical Sciences, Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5702-4116","authenticated-orcid":false,"given":"Preben","family":"Kj\u00f6lhede","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology in Link\u00f6ping Link\u00f6ping University  Link\u00f6ping Sweden"},{"name":"Department of Biomedical and Clinical Sciences Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz","family":"Marcickiewicz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Halland Hospital  Varberg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences Link\u00f6ping University  Link\u00f6ping Sweden"},{"name":"Department of Oncology Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5527-8796","authenticated-orcid":false,"given":"Karin","family":"St\u00e5lberg","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"\u00c5vall\u2010Lundqvist","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences Link\u00f6ping University  Link\u00f6ping Sweden"},{"name":"Department of Oncology Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christer","family":"Borgfeldt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sk\u00e5ne University Hospital, Lund University  Lund 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