{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:21Z","timestamp":1787013861343,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005744","name":"Lastentautien Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005744","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008488","name":"Stiftelsen Alma och K. A. 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These data are important for safety, since another inhibitor of prostaglandin synthesis is harmful to infants born very preterm and increases serious morbidity. We studied whether the use of paracetamol had an adverse influence on neonatal adaptation and the outcomes of infants during the first hospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>We studied the patient records of high\u2010risk mothers and their infants born before 32\u2009weeks of gestation for multiple variables over a period of 84\u2009months in Oulu University Hospital, a regional tertiary care hospital caring for high\u2010risk deliveries and providing neonatal intensive care. In a matched cohort setting, the exposition was defined as paracetamol use &lt;24\u2009h before childbirth. The controls had consumed no paracetamol up to 1\u2009week before delivery. Infants with major anomalies were excluded. The primary outcome was defined as the need for early interventional treatments for the preterm infants. Outcomes during the first hospitalization were also studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Altogether, 170 fetuses from 149 mothers were exposed to paracetamol during the study period. The control population, delivering during the same period, consisted of 118 non\u2010exposed fetuses from 104 mothers. Among them, the mothers were pairwise matched according to their medications, amniotic fluid leakage time, clinical infections, and delivery mode. After matching, 72 mothers\/group remained, resulting in 88 paracetamol\u2010exposed infants and 85 controls. No perinatal adverse reactions were detected. There were no differences in either circulatory support during the first postnatal day or in the risk for major diseases during the first hospitalization. Paracetamol\u2010exposed infants needed fewer acute delivery room therapies (51.1% vs 65.9%, mean difference \u221214.89; 95% confidence interval \u22120.29 to \u22120.003). Maternal total paracetamol dose in the 1\u2009week before delivery correlated positively with Apgar scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Antenatal paracetamol given within 24\u2009h before birth had no adverse effects on extremely or very preterm infants. The long\u2010term safety of paracetamol and the potential acute benefits for preterm infants during perinatal transition remain to be proven in larger, prospective settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.14405","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T01:08:45Z","timestamp":1655341725000},"page":"901-909","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Paracetamol preceding very preterm birth: Is it safe?"],"prefix":"10.1111","volume":"101","author":[{"given":"Aliisa","family":"Laitala","sequence":"first","affiliation":[{"name":"PEDEGO Research Unit and MRC Oulu, University of Oulu and Department of Children and Adolescents Oulu University Hospital  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Saarela","sequence":"additional","affiliation":[{"name":"PEDEGO Research Unit and MRC Oulu, University of Oulu and Department of Children and Adolescents Oulu University Hospital  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marja","family":"V\u00e4\u00e4r\u00e4sm\u00e4ki","sequence":"additional","affiliation":[{"name":"PEDEGO Research Unit and MRC Oulu, University of Oulu, Oulu, Finland, and Department of Obstetrics and Gynecology Oulu University Hospital  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Hallman","sequence":"additional","affiliation":[{"name":"PEDEGO Research Unit and MRC Oulu, University of Oulu and Department of Children and Adolescents Oulu University Hospital  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8267-8621","authenticated-orcid":false,"given":"Outi","family":"Aikio","sequence":"additional","affiliation":[{"name":"PEDEGO Research Unit and MRC Oulu, University of Oulu and Department of Children and 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