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Accumulating evidence has suggested that aberrant miRNA\u2010mRNA interactions are involved in the pathogenesis and progression of ovarian endometriosis. This study aims to identify key miRNAs in ovarian endometriosis by using integrated bioinformatic analysis of a dysregulated miRNA\u2010mRNA co\u2010expression network.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Expression profiling of miRNA and mRNA in three normal endometria and five pairs of ectopic\/eutopic endometria from patients with ovarian endometriosis was determined by high\u2010throughput sequencing techniques. The data were then integrated with the public sequencing datasets (GSE105764 and GSE105765) using a non\u2010biased approach and a miRNA\u2010mRNA co\u2010expression regulatory network was constructed by in\u2010depth bioinformatic analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The constructed miRNA\u2010mRNA network included 87 functionally DEMs, 482 target mRNAs and 1850 paired miRNA\u2010mRNA regulatory interactions. Specifically, five miRNAs (miR\u2010141\u20103p, miR\u2010363\u20103p, miR\u2010577, miR\u2010767\u20105p, miR\u201096\u20105p) were gradually decreased and two miRNAs (miR\u2010493\u20105p, miR\u2010592) were gradually increased from normal endometria to eutopic endometria, and then ectopic endometria tissues. Importantly, miR\u2010141\u20103p, miR\u2010363\u20103p and miR\u201096\u20105p belonged to the miR\u2010200 family, miR\u2010106a\u2010363 cluster and miR\u2010183\/96\/182 cluster, respectively. Their target mRNAs were mainly associated with cell adhesion, locomotion and binding, which are suggested to play vital regulatory roles in the pathogenesis of ovarian endometriosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Integrated bioinformatic analysis of the miRNA\u2010mRNA co\u2010expression network defines the crucial roles of the miR\u2010200 family, miR\u2010106a\u2010363 cluster and miR\u2010183\/96\/182 cluster in the pathogenesis of ovarian endometriosis. Further in\u2010depth functional studies are needed to unveil the molecular mechanisms of these miRNAs, and may provide clues for the optimization of therapeutic strategies for ovarian endometriosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14430","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T09:55:44Z","timestamp":1658742944000},"page":"1074-1084","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Integrated bioinformatic analysis of dysregulated <scp>microRNA\u2010mRNA<\/scp> co\u2010expression network in ovarian endometriosis"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2030-643X","authenticated-orcid":false,"given":"Yong","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gynecology, Beijing Obstetrics and Gynecology Hospital Capital Medical University. 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Beijing Maternal and Child Health Care Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Beijing Obstetrics and Gynecology Hospital Capital Medical University. Beijing Maternal and Child Health Care Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Beijing Obstetrics and Gynecology Hospital Capital Medical University. Beijing Maternal and Child Health Care Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengmao","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Beijing Obstetrics and Gynecology Hospital Capital Medical University. Beijing Maternal and Child Health Care Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Beijing Obstetrics and Gynecology Hospital Capital Medical University. Beijing Maternal and Child Health Care Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Beijing Obstetrics and Gynecology Hospital Capital Medical University. Beijing Maternal and Child Health Care Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Beijing Obstetrics and Gynecology Hospital Capital Medical University. 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