{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T10:50:19Z","timestamp":1792839019981,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Complete resection after debulking surgery is strongly associated with prolonged survival for advanced serous ovarian cancer (ASOC). Though positron emission tomography\/computed tomography (PET\/CT) is more advantageous than computed tomorgraphy (CT) for detecting metastases, studies on the PET\/CT prediction model for incomplete resection for ovarian cancer are insufficient. We analyzed and compared the predictive value of preoperative PET\/CT score, CT score, metabolic parameters, tumor markers and hematological markers for incomplete resection after debulking surgery for ASOC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A total of 62 ASOC patients who underwent preoperative [<jats:sup>18<\/jats:sup>F]FDG PET\/CT and debulking surgery were retrospectively analyzed. PET\/CT and CT scores were based on the Suidan model. The predictive value of PET\/CT score, CT score, the maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), human epididymis protein 4 (HE4), cancer antigen 125 (CA125), lymphocyte\u2010to\u2010monocyte ratio (LMR), platelet\u2010to\u2010lymphocyte ratio (PLR) and neutrophil\u2010to\u2010lymphocyte ratio (NLR) for incomplete resection were analyzed and compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Preoperative PET\/CT score had the highest predictive value for incomplete resection in primary debulking surgery group (sensitivity: 65.0%, specificity: 88.9%, area under the ROC curve (AUC): 0.847, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), however, in secondary debulking surgery group, preoperative PET\/CT score and CT score had the same and highest predictive value for incomplete resection (sensitivity: 80.0%, specificity: 94.7%, AUC: 0.853, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.017), compared with preoperative metabolic parameters SUVmax and MTV, tumor markers HE4 and CA125, and hematological markers LMR, PLR and NLR. Preoperative PET\/CT score\u2009\u2265\u20093 (Suidan model) and preoperative PET\/CT score\u2009\u2265\u20092 predicted a high risk of incomplete resection after primary and secondary debulking surgeries, respectively. There was no statistical difference between primary and secondary debulking surgery groups in predictive value of PET\/CT score for incomplete resection (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.971). There were significant differences between PET\/CT scores and CT scores in primary debulking surgery group and no significant differences in secondary debulking surgery group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A high PET\/CT score predicted a high risk of incomplete resection. The preoperative PET\/CT score had an identical predictive value in primary and secondary debulking surgery groups. PET\/CT score was more accurate in the detection of metastases than CT score was.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14442","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T11:05:46Z","timestamp":1660820746000},"page":"1315-1327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Preoperative <scp>PET<\/scp>\/<scp>CT<\/scp> score can predict incomplete resection after debulking surgery for advanced serous ovarian cancer better than <scp>CT<\/scp> score, <scp>MTV<\/scp>, tumor markers and hematological markers"],"prefix":"10.1111","volume":"101","author":[{"given":"Jie","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine The First Affiliated Hospital of Chongqing Medical University  Chongqing 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5558-9738","authenticated-orcid":false,"given":"Yongmei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21456"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr421"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62223-6"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.05.040"},{"issue":"3","key":"e_1_2_11_6_1","article-title":"Laparoscopy for diagnosing resectability of disease in women with advanced ovarian cancer","volume":"2019","author":"Vrie 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