{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T02:52:52Z","timestamp":1785207172922,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","award":["NNF 130C0002689"],"award-info":[{"award-number":["NNF 130C0002689"]}],"id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The aim was to investigate whether common pregnancy\u2010related symptoms\u2014nausea, vomiting, back pain, pelvic girdle pain, pelvic cavity pain, vaginal bleeding, itching of vulva, pregnancy itching, leg cramps, uterine contractions and varicose veins\u2014in the first trimester of pregnancy add to the identification of women at high risk of future pregnancy and birth complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Survey data linked to national register data. All women booking an appointment for a first prenatal visit in one of 192 randomly selected General Practices in East Denmark in the period April 2015\u2013August 2016. The General Practices included 1491 women to this prospective study. Two outcomes, pregnancy complications and birth complications, were collected from the Danish Medical Birth Register.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 1413 included women, 199 (14%) experienced complications in later pregnancy. The most serious complication, miscarriage, was experienced by 65 women (4.6%). Other common pregnancy complications were gestational diabetes mellitus (<jats:italic>n<\/jats:italic>\u00a0=\u00a011, 0.8%), gestational hypertension without proteinuria (<jats:italic>n<\/jats:italic>\u00a0=\u00a034, 2.4%), mild to moderate preeclampsia (<jats:italic>n<\/jats:italic>\u00a0=\u00a034, 2.4%) and gestational itching with effect on liver (<jats:italic>n<\/jats:italic>\u00a0=\u00a017, 1.2%). Women who experienced pelvic girdle pain, pelvic cavity pain or vaginal bleeding in the first trimester of pregnancy had a higher risk of pregnancy complications later on in later pregnancy. None of the other examined symptoms showed associations to pregnancy complications. No associations were found between pregnancy\u2010related physical symptoms in first trimester and birth complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Symptoms in early pregnancy do not add much information about the risk of pregnancy or birth complications, although pain and bleeding may give reason for some concern. This is an important message to women experiencing these common symptoms and to their caregivers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14474","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T12:29:43Z","timestamp":1666873783000},"page":"33-42","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The predictive value of common symptoms in early pregnancy for complications later in pregnancy and at birth"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4629-3518","authenticated-orcid":false,"given":"Ruth Kirk","family":"Ertmann","sequence":"first","affiliation":[{"name":"Research Unit for General Practice and Section for General Practice Institute of Public Health, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagny Ros","family":"Nicolaisdottir","sequence":"additional","affiliation":[{"name":"Research Unit for General Practice and Section for General Practice Institute of Public Health, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Kragstrup","sequence":"additional","affiliation":[{"name":"Research Unit for General Practice and Section for General Practice Institute of Public Health, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gritt","family":"Overbeck","sequence":"additional","affiliation":[{"name":"Research Unit for General Practice and Section for General Practice Institute of Public Health, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margit","family":"Kriegbaum","sequence":"additional","affiliation":[{"name":"Research Unit for General Practice and Section for General Practice Institute of Public Health, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volkert","family":"Siersma","sequence":"additional","affiliation":[{"name":"Research Unit for General Practice and Section for General Practice Institute of Public Health, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12468"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3399\/bjgpopen19X101674"},{"key":"e_1_2_10_4_1","first-page":"2897","article-title":"Preventive check\u2010ups of pregnant women in Denmark. 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Bleeding during pregnancy [Bl\u00f8dning i graviditeten \u2010 L\u00e6geh\u00e5ndbogen p\u00e5 sundhed.dk]. 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