{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:10:04Z","timestamp":1791465004531,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T00:00:00Z","timestamp":1673827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010100","name":"Sykehuset \u00d8stfold","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010100","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Human papillomavirus (HPV) infection is common in women of reproductive age. Infection and inflammation are leading causes for preterm delivery (PTD), but the role of HPV infection in PTD and prelabor rupture of membranes (PROM) is unclear. We aimed to explore whether HPV infection during pregnancy in general, and high\u2010risk\u2010HPV (HR\u2010HPV) infection specifically, increased the risk of PTD, preterm prelabor rupture of membranes (PPROM), PROM at term, and\/or chorioamnionitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>In pregnant women, who were participating in a prospective multicenter cohort study from a general population in Norway and Sweden (PreventADALL, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link> NCT02449850), HPV DNA was analyzed in available urine samples at mid\u2010gestation (16\u201322\u2009weeks) and at delivery, and in the placenta after delivery with Seegene Anyplex II HPV28 PCR assay. The risk of PTD, PPROM, PROM, and chorioamnionitis was analyzed using unadjusted and adjusted logistic regression analyses for any 28 HPV genotypes, including 12 HR\u2010HPV genotypes, compared with HPV\u2010negative women. Further, subgroups of HPV (low\u2010risk\/possibly HR\u2010HPV, HR\u2010HPV\u2010non\u201016 and HR\u2010HPV\u201016), persistence of HR\u2010HPV from mid\u2010gestation to delivery, HR\u2010HPV\u2010viral load, and presence of multiple HPV infections were analyzed for the obstetric outcomes. Samples for HPV analyses were available from 950 women with singleton pregnancies (mean age 32\u2009years) at mid\u2010gestation and in 753 also at delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At mid\u2010gestation, 40% of women were positive for any HPV and 24% for HR\u2010HPV. Of the 950 included women, 23 had PTD (2.4%), nine had PPROM (0.9%), and six had chorioamnionitis (0.6%). Of the term pregnancies, 25% involved PROM. The frequency of PTD was higher in HR\u2010HPV\u2010positive women (8\/231, 3.5%) than in HPV\u2010negative women (13\/573, 2.3%) at mid\u2010gestation, but the association was not statistically significant (odds ratio 1.55; 95% confidence interval 0.63\u20133.78). Neither any HPV nor subgroups of HPV at mid\u2010gestation or delivery, nor persistence of HR\u2010HPV was significantly associated with increased risk for PTD, PPROM, PROM, or chorioamnionitis. No HPV DNA was detected in placentas of women with PTD, PPROM or chorioamnionitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HPV infection during pregnancy was not significantly associated with increased risk for PTD, PPROM, PROM, or chorioamnionitis among women from a general population with a low incidence of adverse obstetric outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14509","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T05:21:15Z","timestamp":1673932875000},"page":"344-354","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Maternal human papillomavirus infection during pregnancy and preterm delivery: A mother\u2013child cohort study in Norway and Sweden"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9441-2035","authenticated-orcid":false,"given":"Johanna","family":"Wiik","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics \u00d8stfold Hospital Trust  Gralum Norway"},{"name":"Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Obstetrics and Gynecology Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena R.","family":"V\u00e6rnesbranden","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics \u00d8stfold Hospital Trust  Gralum Norway"},{"name":"Institute of Clinical Medicine, Faculty of Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Jonassen","sequence":"additional","affiliation":[{"name":"Department of Virology, Norwegian Institute of Public Health Oslo  Oslo Norway"},{"name":"Genetic Unit, Center for Laboratory Medicine \u00d8stfold Hospital Trust  Gralum Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Cathrine","family":"Staff","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, Faculty of Medicine University of Oslo  Oslo Norway"},{"name":"Division of Obstetrics and Gynecology Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin C. L.","family":"Carlsen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, Faculty of Medicine University of Oslo  Oslo Norway"},{"name":"Division of Pediatric and Adolescent Medicine Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berit","family":"Granum","sequence":"additional","affiliation":[{"name":"Department of Chemical Toxicology, Norwegian Institute of Public Health  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8383-5393","authenticated-orcid":false,"given":"Guttorm","family":"Haugen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, Faculty of Medicine University of Oslo  Oslo Norway"},{"name":"Division of Obstetrics and Gynecology Oslo University Hospital  Oslo 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Sweden"},{"name":"Department of Obstetrics and Gynecology Sahlgrenska University Hospital  Gothenburg Sweden"},{"name":"Department of Genetics and Bioinformatics, Division of Health Data and Digitalization, Institute of Public Health  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Staffan","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Mathematical Sciences Chalmers University of Technology  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Nordlund","sequence":"additional","affiliation":[{"name":"Astrid Lindgren Children's Hospital, Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Women's and Children's Health Karolinska Institutet  Stockholm 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