{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T19:23:05Z","timestamp":1792264985304,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013500","name":"Finnish Diabetes Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013500","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004037","name":"Juho Vainion S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004037","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010129","name":"Maud Kuistilan Muistos\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004212","name":"P\u00e4ivikki and Sakari Sohlberg Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004212","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008723","name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2023,4]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n To explore the role of maternal anthropometric characteristics in early\u2010pregnancy glycemia, we analyzed the associations and interactions of maternal early\u2010pregnancy waist circumference (WC), height and pre\u2010pregnancy body mass index (BMI) with plasma glucose concentrations in an oral glucose tolerance test (OGTT) at 12\u201316\u2009weeks\u2019 gestation.<\/jats:p>\n <\/jats:sec>\n \n Material and Methods<\/jats:title>\n \n A population\u2010based cohort of 1361 pregnant women was recruited in South Karelia, Finland, from March 2013 to December 2016. All participants had their WC, weight, height, HbA\n 1c<\/jats:sub>\n , and blood pressure measured at 8\u201314\u2009weeks\u2019 gestation and subsequently underwent a 2\u2010h 75\u2010g OGTT, including assessment of fasting insulin concentrations, at 12\u201316\u2009weeks\u2019 gestation. BMI (kg\/m\n 2<\/jats:sup>\n ) was calculated using self\u2010reported pre\u2010pregnancy weight. Maternal WC \u226580\u2009cm was defined as large. Maternal height \u2265166\u2009cm was defined as tall. Data on gestational diabetes treatment was extracted from hospital records.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In the total cohort, 901 (66%) of women had an early\u2010pregnancy WC \u226580\u2009cm, which was associated with higher early\u2010pregnancy HbA\n 1c,<\/jats:sub>\n higher\u00a0concentrations\u00a0of\u00a0\u00a0fasting plasma glucose and serum insulin, higher\u00a0post\u2010load plasma glucose concentrations, higher\u00a0HOMA\u2010IR indices, higher blood pressure levels, and higher\u00a0frequencies of pharmacologically treated gestational diabetes, than early\u2010pregnancy WC <80\u2009cm. Maternal height \u2265166\u2009cm was negatively associated with 1\u2010 and 2\u2010h post\u2010load plasma glucose concentrations. Waist\u2010to\u2010height ratio (WHtR) >0.5 was positively associated with both fasting and post\u2010load plasma glucose concentrations at 12\u201316\u2009weeks\u2019 gestation, even when adjusted for age, smoking, nulliparity, and family history of type 2 diabetes. The best cut\u2010offs for WHtR (0.58 for 1\u2010h plasma glucose, and 0.54 for 2\u2010h plasma glucose) were better predictors of post\u2010load glucose concentrations >90th percentile than the best cut\u2010offs for BMI (28.1\u00a0kg\/m\n 2<\/jats:sup>\n for 1\u2010h plasma glucose, and 26.6\u00a0kg\/m\n 2<\/jats:sup>\n for 2\u2010h plasma glucose), with areas\u2010under\u2010the\u2010curve (95% confidence interval) 0.73 (0.68\u20130.79) and 0.73 (0.69\u20130.77), respectively, for WHtR, and 0.68 (0.63\u20130.74) and 0.69 (0.65\u20130.74), respectively, for BMI.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n In our population\u2010based cohort, early\u2010pregnancy WHtR >0.5 was\u00a0positively associated\u00a0with both fasting and post\u2010load glucose concentrations at 12\u201316\u2009weeks\u2019 gestation and performed better than BMI in the prediction of post\u2010load glucose concentrations >90th percentile. Overall, our results underline the importance of evaluating maternal abdominal adiposity in gestational diabetes risk assessment.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/aogs.14528","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T05:48:54Z","timestamp":1676612934000},"page":"496-505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Large maternal waist circumference in relation to height is associated with high glucose concentrations in an early\u2010pregnancy oral glucose tolerance test: A population\u2010based study"],"prefix":"10.1111","volume":"102","author":[{"given":"Mervi","family":"Jokelainen","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology South Karelia Central Hospital Lappeenranta Finland"},{"name":"Department of Obstetrics and Gynecology University of Helsinki and Helsinki University Hospital Helsinki 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