{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T23:57:39Z","timestamp":1784591859633,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001102","name":"Cancer Council NSW","doi-asserted-by":"publisher","award":["reference RG 18\u201002"],"award-info":[{"award-number":["reference RG 18\u201002"]}],"id":[{"id":"10.13039\/501100001102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Pregnancy\u2010associated gynecological cancer (PAGC) refers to cancers of the ovary, uterus, fallopian tube, cervix, vagina, and vulva diagnosed during pregnancy or within 12\u2009months postpartum. We aimed to describe the incidence of, and perinatal outcomes associated with, invasive pregnancy\u2010associated gynecological cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>We conducted a population\u2010based historical cohort study using linked data from New South Wales, Australia. We included all women who gave birth between 1994 and 2013, with a follow\u2010up period extending to September 30, 2018. Three groups were analyzed: a gestational PAGC group (women diagnosed during pregnancy), a postpartum PAGC group (women diagnosed within 1\u2009year of giving birth), and a control group (women with control diagnosis during pregnancy or within 1\u2009year of giving birth). We used generalized estimation equations to compare perinatal outcomes between study groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 1\u00a0786\u2009137 deliveries during the study period; 70 women were diagnosed with gestational PAGC and 191 with postpartum PAGC. The incidence of PAGC was 14.6\/100\u2009000 deliveries and did not change during the study period. Women with gestational PAGC (adjusted odds ratio [aAOR] 6.81, 95% confidence interval [CI] 2.97\u201315.62) and with postpartum PAGC (aOR 2.65, 95% CI 1.25\u20135.61) had significantly increased odds of a severe maternal morbidity outcome compared with the control group. Babies born to women with gestational PAGC were more likely to be born preterm (aOR 3.11, 95% CI 1.47\u20136.59) and were at increased odds of severe neonatal complications (aOR 3.47, 95% CI 1.45\u20138.31) compared with babies born to women without PAC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of PAGC has not increased over time perhaps reflecting, in part, the effectiveness of cervical screening and early impacts of human papillomavirus vaccination programs in Australia. The higher rate of preterm birth among the gestational PAGC group is associated with adverse outcomes in babies born to these women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14530","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T05:40:53Z","timestamp":1678772453000},"page":"729-739","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pregnancy\u2010associated gynecological cancer in New South Wales, Australia 1994\u20132013: A population\u2010based historical cohort study"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1853-8194","authenticated-orcid":false,"given":"Penelope","family":"Fotheringham","sequence":"first","affiliation":[{"name":"College of Health, Medicine and Wellbeing University of Newcastle  Callaghan New South Wales Australia"},{"name":"Hunter Medical Research Institute  New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8473-0980","authenticated-orcid":false,"given":"Nadom","family":"Safi","sequence":"additional","affiliation":[{"name":"College of Health, Medicine and Wellbeing University of Newcastle  Callaghan New South Wales Australia"},{"name":"Hunter Medical Research Institute  New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouyang","family":"Li","sequence":"additional","affiliation":[{"name":"College of Health, Medicine and Wellbeing University of Newcastle  Callaghan New South Wales Australia"},{"name":"Hunter Medical Research Institute  New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoinette","family":"Anazodo","sequence":"additional","affiliation":[{"name":"Nelune Comprehensive Cancer Centre Prince of Wales Hospital  Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7796-4447","authenticated-orcid":false,"given":"Marc","family":"Remond","sequence":"additional","affiliation":[{"name":"College of Health, Medicine and Wellbeing University of Newcastle  Callaghan New South Wales Australia"},{"name":"Hunter Medical Research Institute  New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hayen","sequence":"additional","affiliation":[{"name":"School of Public Health University of Technology Sydney  Ultimo New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Currow","sequence":"additional","affiliation":[{"name":"Faculty of Science, Medicine and Health University of Wollongong  Wollongong New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Roder","sequence":"additional","affiliation":[{"name":"Population Health, Beat Cancer Project University of South Australia  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Hamad","sequence":"additional","affiliation":[{"name":"The Kinghorn Cancer Centre  Darlinghurst New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Nicholl","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health The University of Sydney  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne","family":"Gordon","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health The University of Sydney  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Frawley","sequence":"additional","affiliation":[{"name":"School of Public Health University of Technology Sydney  Ultimo New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"College of Health, Medicine and Wellbeing University of Newcastle  Callaghan New South Wales Australia"},{"name":"Hunter Medical Research Institute  New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12621"},{"key":"e_1_2_12_3_1","unstructured":"World Health Organisation.Cervical Cancer.2022. 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CAN 66.AIHW;2012."},{"key":"e_1_2_12_27_1","first-page":"179","article-title":"Cervical cancer complicated by pregnancy: episiotomy site recurrences following vaginal delivery","volume":"84","author":"Cliby WA","year":"1994","journal-title":"Obstet Gynecol"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/tog.12367"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1536117"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e318178eae4"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.14530","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aogs.14530","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.14530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T18:18:31Z","timestamp":1744309111000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.14530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,13]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/aogs.14530"],"URL":"https:\/\/doi.org\/10.1111\/aogs.14530","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,13]]},"assertion":[{"value":"2022-09-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}