{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:07:42Z","timestamp":1788984462514,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>According to a precautionary principle, it is recommended that pregnant women and women trying to conceive abstain from alcohol consumption. In this dose\u2013response meta\u2010analysis, we aimed to examine the association between alcohol consumption and binge drinking and the risk of miscarriage in the first and second trimesters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>The literature search was conducted in MEDLINE, Embase and the Cochrane Library in May 2022, without any language, geographic or time limitations. Cohort or case\u2013control studies reporting dose\u2010specific effects adjusting for maternal age and using separate risk assessments for first\u2010 and second\u2010trimester miscarriages were included. Study quality was assessed using the Newcastle\u2013Ottawa Scale. This study is registered with PROSPERO, registration number CRD42020221070.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 2124 articles were identified. Five articles met the inclusion criteria. Adjusted data from 153\u2009619 women were included in the first\u2010trimester analysis and data from 458\u2009154 women in the second\u2010trimester analysis. In the first and second trimesters, the risk of miscarriage increased by 7% (odds ratio [OR] 1.07, 95% confidence interval [CI] 0.96\u20131.20) and 3% (OR 1.03, 95% CI 0.99\u20131.08) for each additional drink per week, respectively, but not to a statistically significant degree. One article regarding binge drinking and the risk of miscarriage was found, which revealed no association between the variables in either the first or second trimester (OR 0.84 [95% CI 0.62\u20131.14] and OR 1.04 [95% CI 0.78\u20131.38]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This meta\u2010analysis revealed no dose\u2010dependent association between miscarriage risk and alcohol consumption, but further focused research is recommended. The research gap regarding miscarriage and binge drinking needs further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14566","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T05:49:03Z","timestamp":1684907343000},"page":"821-832","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Maternal alcohol consumption and the risk of miscarriage in\u00a0the first and second trimesters: A systematic review and\u00a0dose\u2013response meta\u2010analysis"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6283-0083","authenticated-orcid":false,"given":"Kristina Rantzau","family":"Saxov","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"},{"name":"Department of Obstetrics and Gynecology Aalborg University Hospital  Aalborg 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