{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:10:59Z","timestamp":1789665059196,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","award":["R247\u2010A14608"],"award-info":[{"award-number":["R247\u2010A14608"]}],"id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>To assess outcome of a one\u2010time human papillomavirus (HPV)\u2010screening in 2017 of Danish women aged 70+.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Women born 1947 or before were personally invited to have a cell\u2010sample collected by their general practitioner. Screening\u2010 and follow\u2010up samples were analyzed in hospital laboratories in the five Danish regions and registered centrally. Follow\u2010up procedures varied slightly across regions. Cervical intraepithelial neoplasia 2 (CIN2) was recommended treatment threshold. Data were retrieved from the Danish Quality Database for Cervical Cancer Screening. We calculated CIN2+ and CIN3+ detection rates per 1000 screened women, and number of biopsies and conizations per detected CIN2+ case. We tabulated annual number of incident cervical cancer cases in Denmark for the years 2009\u20132020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 359\u2009763 women were invited of whom 108\u2009585 (30% of invited) were screened; 4479 (4.1% of screened, and 4.3% of screened 70\u201374\u2009years) tested HPV\u2010positive; of whom 2419 (54% of HPV\u2010positive) were recommended follow\u2010up with colposcopy, biopsy and cervical sampling, and 2060 with cell\u2010sample follow\u2010up. In total, 2888 women had histology; of whom 1237 cone specimen and 1651 biopsy only. Out of 1000 screened women 11 (95% confidence interval [CI]: 11\u201312) had conization. In total, 579 women had CIN2+; 209 CIN2, 314 CIN3, and 56 cancer. Out of 1000 screened women five (95% CI: 5\u20136) had CIN2+. Detection rate of CIN2+ was highest in regions where conization was used as part of first\u2010line follow\u2010up. In 2009\u20132016, number of incident cervical cancers in women aged 70+ in Denmark fluctuated around 64; in 2017 it reached 83 cases; and by 2021 the number had decreased to 50.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of high\u2010risk HPV of 4.3% in women aged 70\u201374 is in agreement with data from Australia, and the detection of five CIN+2 cases per 1000 screened women is in agreement with data for 65\u201369\u2009year old women in Norway. Data are thus starting to accumulate on primary HPV\u2010screening of elderly women. The screening resulted in a prevalence peak in incident cervical cancers, and it will therefore take some years before the cancer preventive effect of the screening can be evaluated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14574","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T05:34:28Z","timestamp":1682660068000},"page":"791-800","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A cervical screening initiative for elderly women in Denmark"],"prefix":"10.1111","volume":"102","author":[{"given":"Malene","family":"Skorstengaard","sequence":"first","affiliation":[{"name":"Nyk\u00f8bing Falster Hospital  Nyk\u00f8bing Falster Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra Hall","family":"Viborg","sequence":"additional","affiliation":[{"name":"Danish Clinical Registries (RKKP)  Frederiksberg\/Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ane Birgitte","family":"Tel\u00e9n\u00a0Andersen","sequence":"additional","affiliation":[{"name":"Danish Clinical Registries (RKKP)  Frederiksberg\/Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berit","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Public Health Programs University Research Clinic for Cancer Screening, Randers Regional Hospital  Randers Denmark"},{"name":"Department of Clinical Medicine Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Holten\u00a0Bennetsen","sequence":"additional","affiliation":[{"name":"Department of Pathology Randers Regional Hospital  Randers Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten Marie","family":"Jochumsen","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonje","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Pathology Randers Regional Hospital  Randers Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise Grupe","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Pathology Zealand Regional Hospital  N\u00e6stved\/Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja Ulrikka","family":"Bruun\u00a0Laustsen","sequence":"additional","affiliation":[{"name":"Danish Clinical Registries (RKKP)  Frederiksberg\/Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rouzbeh","family":"Salmani","sequence":"additional","affiliation":[{"name":"Department of Pathology Zealand Regional Hospital  N\u00e6stved\/Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Serizawa","sequence":"additional","affiliation":[{"name":"Department of Pathology Hvidovre Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Waldstr\u00f8m","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4785-5236","authenticated-orcid":false,"given":"Elsebeth","family":"Lynge","sequence":"additional","affiliation":[{"name":"Nyk\u00f8bing Falster Hospital  Nyk\u00f8bing Falster Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,27]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57149"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.12.021"},{"key":"e_1_2_13_4_1","unstructured":"Danish Cancer Register.[Incident cancer cases]. Accessed June 12 2020.https:\/\/www.esundhed.dk\/Registre\/Cancerregisteret\/Nye\u2010kraefttilfaelde. [In Danish]."},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2019.04.680"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0246902"},{"key":"e_1_2_13_7_1","unstructured":"Danish Quality Database for Cervical Cancer Screening.[Results of the one\u2010time screening: Cervical screening in Danish women born before 1948 \u2013 1st Report.] 2019. [In Danish]."},{"key":"e_1_2_13_8_1","unstructured":"Danish Quality Database for Cervical Cancer Screening.[Results of the one\u2010time screening: Cervical screening in Danish women born before 1948 \u2013 2nd Report.] 2019. [In Danish]."},{"key":"e_1_2_13_9_1","unstructured":"Danish Society for Obstetrics and Gynecology.[Diagnosis treatment and control of cervical dysplasia 2012;1\u201330]. [In Danish]."},{"key":"e_1_2_13_10_1","unstructured":"Statistics Denmark. Accessed January 4 2022.https:\/\/www.dst.dk\/da\/Statistik\/emner\/borgere\/befolkning\/befolkningstal"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28586"},{"key":"e_1_2_13_12_1","unstructured":"[Danish gynecological cancer database] [In Danish]. Accessed January 16 2023.https:\/\/www.sundhed.dk\/content\/cms\/80\/4680_dgcd\u2010aarsrapport\u20102021\u20102022\u2010offentliggjort\u2010version\u201020221220.pdf"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(22)00241-8"},{"key":"e_1_2_13_14_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2021-068582","article-title":"National experience in the first two years of primary human papillomavirus (HPV) cervical screening in an HPV vaccinated population in Australia: observational study","volume":"376","author":"Smith MA","year":"2022","journal-title":"BMJ"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0189300"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-22-0340"},{"key":"e_1_2_13_17_1","unstructured":"AlbinusN\u2010B.[Women aged 100\u2009years invited for cervical screening]. Dagens Medicin 17 August 2017 [in Danish]. Accessed March 8 2021.https:\/\/dagensmedicin.dk\/100\u2010aarige\u2010indkaldes\u2010screening\u2010livmoderhalskraeft\/"},{"key":"e_1_2_13_18_1","unstructured":"KlarskovN LoseG.[Absurd screening offer to elderly women]. Dagens Medicin 24 August 2017 [in Danish]. Accessed March 8 2021.https:\/\/dagensmedicin.dk\/absurd\u2010screeningstilbud\u2010aeldre\u2010kvinder\/"},{"key":"e_1_2_13_19_1","unstructured":"RasmussenEA. [response].https:\/\/dagensmedicin.dk\/100\u2010aarige\u2010indkaldes\u2010screening\u2010livmoderhalskraeft\/. Dagens Medicin 25 August 2017 [in Danish]."},{"key":"e_1_2_13_20_1","unstructured":"Danish Society for Obstetrics and Gynecology.[National guidelines for cervical cellular abnormalities. Women aged 60 and above]. 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