{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:33:31Z","timestamp":1792809211938,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T00:00:00Z","timestamp":1682208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>This study examined obstetric outcomes in patients diagnosed with uterine adenomyosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>This historical cohort study queried the Healthcare Cost and Utilization Project's National Inpatient Sample. The study population was all hospital deliveries in women aged 15\u201354\u2009years between January 2016 and December 2019. The exposure was a diagnosis of uterine adenomyosis. The main outcome measures were obstetric characteristics, including placenta previa, placenta accreta spectrum, and placental abruption. Secondary outcomes were delivery complications including severe maternal morbidity. Analytic steps to assess these outcomes included (i) a 1\u2010to\u2010<jats:italic>N<\/jats:italic> propensity score matching to mitigate and balance prepregnancy confounders to assess obstetric characteristics, followed by (ii) an adjusting model with preselected pregnancy and delivery factors to assess maternal morbidity. Sensitivity analyses were also performed with restricted cohorts to account for prior uterine scar, uterine myoma, and extra\u2010uterine endometriosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After propensity score matching, 5430 patients with adenomyosis were compared to 21\u2009720 patients without adenomyosis. Adenomyosis was associated with an increased odds of placenta accreta spectrum (adjusted\u2010odds ratio [aOR] 3.07, 95% confidence interval [CI] 2.01\u20134.70), placenta abruption (aOR 3.21, 95% CI: 2.60\u20133.98), and placenta previa (aOR 5.08, 95% CI: 4.25\u20136.06). Delivery at &lt;32\u2009weeks of gestation (aOR 1.48, 95% CI: 1.24\u20131.77) and cesarean delivery (aOR 7.72, 95% CI: 7.04\u20138.47) were both increased in women with adenomyosis. Patients in the adenomyosis group were more likely to experience severe maternal morbidity at delivery compared to those in the nonadenomyosis group (aOR 1.86, 95% CI: 1.59\u20132.16). Results remained robust in the aforementioned several sensitivity analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This national\u2010level analysis suggests that a diagnosis of uterine adenomyosis is associated with an increased risk of placental pathology (placenta accreta spectrum, placenta abruption, and placental previa) and adverse maternal outcomes at delivery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14581","type":"journal-article","created":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T17:48:52Z","timestamp":1682272132000},"page":"833-842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The association between uterine adenomyosis and adverse obstetric outcomes: A propensity score\u2010matched analysis"],"prefix":"10.1111","volume":"102","author":[{"given":"Rachel S.","family":"Mandelbaum","sequence":"first","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel J. F.","family":"Melville","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology University of Southern California  Los Angeles California USA"},{"name":"Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline J.","family":"Violette","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joie Z.","family":"Guner","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlin A.","family":"Doody","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Matsuzaki","sequence":"additional","affiliation":[{"name":"Department of Gynecology Osaka International Cancer Institute  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly M.","family":"Quinn","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph G.","family":"Ouzounian","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine, Department of Obstetrics and Gynecology University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Paulson","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6232-8701","authenticated-orcid":false,"given":"Koji","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology University of Southern California  Los Angeles California USA"},{"name":"Norris Comprehensive Cancer Center University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.06.044"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmz049"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)01962-8"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1718920"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.01.016"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2018.09.014"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1285895"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.06.025"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu041"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2020.09.023"},{"key":"e_1_2_12_12_1","unstructured":"Overview of the National (Nationwide) Inpatient Sample (NIS).Agency for Healthcare Research and Quality. Accessed March 6 2022.https:\/\/www.hcup\u2010us.ahrq.gov\/nisoverview.jsp"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.09.021"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.14699"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.04.233"},{"key":"e_1_2_12_16_1","unstructured":"Severe maternal morbidity in the United States.Centers for Disease Control and Prevention. Accessed March 6 2022.https:\/\/www.cdc.gov\/reproductivehealth\/maternalinfanthealth\/severematernalmorbidity.html"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/00273171.2011.568786"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pst.433"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.07.002"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.09.069"},{"issue":"233","key":"e_1_2_12_21_1","first-page":"e231","article-title":"Confirmed severe maternal morbidity is associated with high rate of preterm delivery","volume":"215","author":"Kilpatrick SJ","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001005"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000219750.79480.84"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2021.0528"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60201-5"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40738-021-00097-4"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.251.231"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/14647273.2020.1720316"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2017.03.035"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2549789"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719115597761"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu004"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2020.07.023"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1716687"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.09.042"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.05.067"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12014-021-09336-8"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2021.12.017"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep474"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2021.102114"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.173491"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2009.07.017"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq311"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S273047"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.14581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T10:26:26Z","timestamp":1743848786000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.14581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,23]]},"references-count":43,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1111\/aogs.14581"],"URL":"https:\/\/doi.org\/10.1111\/aogs.14581","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,23]]},"assertion":[{"value":"2023-01-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}