{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:14:31Z","timestamp":1783530871059,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:00:00Z","timestamp":1692144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013899","name":"M.S.I. Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013899","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Our objective was to explore the relation between patient age and postoperative opioid use up to 24\u2009hours following pelvic organ prolapse (POP) surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>We conducted a prospective cohort study following 335 women ranging in age from 26 to 82\u2009years who underwent surgery for multi\u2010compartment POP at a tertiary center in Alberta, Canada. Patient characteristics were measured using baseline questionnaires. Perioperative data were collected from medical chart review during and up to 24\u2009hours following surgery. We used logistic regression to analyze the odds of being opioid\u2010free and linear regression to analyze mean differences in opioid dose, measured as total morphine equivalent daily dose, exploring for a potential non\u2010linear effect of age. Adjusted models controlled for preoperative pain, surgical characteristics and patient health factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, age was positively associated with greater odds of being opioid\u2010free in the first 24\u2009hours after surgery (adjusted odds ratio per increasing year of age\u2009=\u20091.07, 95% confidence interval [CI] 1.04\u20131.09, <jats:italic>n<\/jats:italic>\u2009=\u2009332 women). Among opioid users, age was inversely associated with total opioid dose (adjusted mean difference per increasing year of age\u2009=\u20090.71\u2009mg morphine equivalent daily dose, 95% CI \u22120.99 to \u22120.44, <jats:italic>n<\/jats:italic>\u2009=\u2009204 women). There was no evidence of a non\u2010linear relation between age and postoperative opioid use or dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the context of POP surgery, we found that younger women were more likely to use opioids after surgery and to use a higher dose in the first 24\u2009hours when compared with older women. These findings support physicians to consider age when counseling POP patients regarding pain management after surgery, and to direct resources aimed at opioid\u2010free pain control towards younger patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14638","type":"journal-article","created":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T21:33:07Z","timestamp":1692567187000},"page":"1371-1377","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Age and postoperative opioid use in women undergoing pelvic organ prolapse surgery"],"prefix":"10.1111","volume":"102","author":[{"given":"Shannon","family":"Cummings","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5811-7661","authenticated-orcid":false,"given":"Natalie V.","family":"Scime","sequence":"additional","affiliation":[{"name":"Department of Health and Society University of Toronto Scarborough  Scarborough Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0500-6060","authenticated-orcid":false,"given":"Erin A.","family":"Brennand","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Department of Community Health Sciences, Cumming School of Medicine University of Calgary  Calgary Alberta 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