{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T18:51:28Z","timestamp":1789843888901,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Pelvic girdle pain during and after pregnancy is a major public health problem with significant daily problems for affected women and their families. There is now accumulating evidence that pregnancy\u2010related pelvic girdle pain originates from the sacroiliac joints and the pubic symphysis as well as their extra\u2010articular ligaments. However, the heritability of the disease remains to be determined. We hypothesized that there is an increased familial risk of pregnancy\u2010related pelvic girdle pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A population\u2010based national database linkage registry study of approximately 9.3\u2009million individuals within 4.2\u2009million families in Sweden with a recruitment period from 1997 to 2018. The Swedish Multi\u2010generation register was used to find female pairs of twins, full siblings, half\u2010siblings and first cousins where both in the pairs had a completed pregnancy. The outcome measure was diagnosis of pregnancy\u2010related pelvic girdle pain (International Classification of Diseases\u201010 O26.7 [1997\u20132018]) in the first pregnancy. Data was obtained from the Swedish Hospital Discharge Register, the Swedish Outpatient Care Register, the Swedish Medical Birth Register, the Primary Healthcare Register, and Medical Treatment Register. Cox regression analysis was used to calculate adjusted estimated effect of the exposure variable familial history of pregnancy\u2010related pelvic girdle pain on the outcome variable pregnancy\u2010related pelvic girdle pain at first birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From the registers, 1\u2009010\u2009064 women pregnant with their first child within 795\u2009654 families were collected. In total, 109\u2009147 women were diagnosed with pregnancy\u2010related pelvic girdle pain. The adjusted hazard ratio for a familial risk of pregnancy\u2010related pelvic girdle pain was 2.09 (95% CI 1.85\u20132.37) among twins (monozygotic and dizygotic), 1.78 (95% CI 1.74\u20131.82) in full siblings, 1.16 (95% CI 1.06\u20131.28) in half\u2010siblings from the mother, 1.09 (95% CI 1.02<jats:styled-content>4<\/jats:styled-content>\u20131.16) in half\u2010siblings from the father and 1.09 (95% CI 1.07\u20131.12) in first cousins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This nationwide observational study showed a familial clustering of pregnancy\u2010related pelvic girdle pain. The hazard ratio for the condition was associated with the degree of relatedness, suggesting that heredity factors contribute to the development of pregnancy\u2010related pelvic girdle pain. There is no causal treatment available for pregnancy\u2010related pelvic girdle pain and further studies are now encouraged to clarify the specific genetic factors that contribute to the disease and for future targeted interventions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14646","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T13:19:16Z","timestamp":1689859156000},"page":"1250-1258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Heredity of pregnancy\u2010related pelvic girdle pain in Sweden"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7346-1674","authenticated-orcid":false,"given":"Per","family":"Kristiansson","sequence":"first","affiliation":[{"name":"Department of Public Health and Caring Sciences Uppsala University  Uppsala 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Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjun","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research Lund University  Lund 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