{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T18:46:31Z","timestamp":1778611591903,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Air pollution is a current major health issue. The burden of airborne pollutants and aeroallergen levels varies throughout the year, as well as their interaction and consequences. Prenatal exposure during pregnancy has been associated with adverse perinatal outcomes. The aim of this study was to evaluate the impact of air pollutants on perinatal outcomes in patients with or without respiratory allergy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Nested case\u2013control retrospective study on 3006 pregnant women. Correlations between concentrations of common pollutants in each trimester of pregnancy and on average during the whole pregnancy and both gestational age at delivery and birthweight were studied. Pearson's correlation coefficient and binary logistic regression were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In general, pollutants correlated more strongly with birthweight than with gestational age at delivery. Nine\u2010month NO<jats:sub>2<\/jats:sub>, SO<jats:sub>2<\/jats:sub>, CO, and benzene, and second\u2010trimester CO negatively correlated with birthweight, whereas only first\u2010trimester NO<jats:sub>2<\/jats:sub> showed a very mild correlation with gestational age at delivery. Negative correlations between pollutants and birthweight were much stronger in the respiratory allergy group (<jats:italic>n<\/jats:italic>\u2009=\u200943; 1.4%) than in the non\u2010allergic group. After adjustments, the most significant predictive pollutant of birthweight was SO<jats:sub>2<\/jats:sub> in both groups. The best predictive model was much stronger in the allergic group for third\u2010trimester SO<jats:sub>2<\/jats:sub> (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.12, <jats:italic>p<\/jats:italic>\u2009=\u20090.02) than in the non\u2010allergic group for total SO<jats:sub>2<\/jats:sub> (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.002, <jats:italic>p<\/jats:italic>\u2009=\u20090.02). For each unit that SO<jats:sub>2<\/jats:sub> increased, birthweight reduced by 3.22% vs. 1.28% in each group, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Air pollutant concentrations, especially SO<jats:sub>2<\/jats:sub>, negatively influenced birthweight. The impact of this association was much stronger and more relevant in the group of women with respiratory allergies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14655","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T02:47:07Z","timestamp":1692672427000},"page":"1593-1601","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The influence of air pollution on gestational age at delivery and birthweight in patients with or without respiratory allergy: A nested case\u2013control study"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3444-4131","authenticated-orcid":false,"given":"Irene","family":"Bartha","sequence":"first","affiliation":[{"name":"Faculty of Medicine Universidad Aut\u00f3noma de Madrid  Madrid Spain"},{"name":"Department of Women and Children's Health (Paediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College London and Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"De\u00a0La\u00a0Fuente","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Faculty of Life Sciences and Medicine King's College London and Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"Martinez\u2010Sanchez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital La Paz  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"De\u00a0La\u00a0Calle","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital La Paz  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Martin\u00a0Boado","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital La Paz  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Luis","family":"Bartha","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universidad Aut\u00f3noma de Madrid  Madrid Spain"},{"name":"Department of Obstetrics and Gynecology University Hospital La Paz  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization.2022.https:\/\/www.who.int"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.14124"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2016.08.069"},{"key":"e_1_2_10_5_1","first-page":"219","article-title":"Interaction between air pollutants and pollen grains: the role on the rising trend in allergy","volume":"6","author":"Sedghy F","year":"2018","journal-title":"Rep Biochem Mol Biol"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2016.04.026"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.105177"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2018.12.470"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40572-020-00284-3"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2018.07.008"},{"issue":"306","key":"e_1_2_10_11_1","first-page":"1","article-title":"Prenatal exposure to ambient air pollution and adverse birth outcomes: an umbrella review of 36 systematic reviews and meta\u2010analyses","volume":"1","author":"Nyadanu SD","year":"2022","journal-title":"Environ Pollut"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2015.11.034"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wombi.2019.03.014"},{"key":"e_1_2_10_14_1","unstructured":"European Health Perinatal Report.2015. 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