{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:37:06Z","timestamp":1791311826292,"version":"4.3.1"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T00:00:00Z","timestamp":1696809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Pre\u2010eclampsia affects 2%\u20138% of pregnancies and is one of the leading causes of maternal and perinatal morbidity and mortality. First\u2010trimester screening using an algorithm that combines maternal characteristics, mean arterial blood pressure, uterine artery pulsatility index and biomarkers (pregnancy\u2010associated plasma protein\u2010A and placental growth factor) is the method that achieves a greater diagnostic accuracy. It has been shown that daily salicylic acid administration before 16\u2009weeks in women at a high risk for pre\u2010eclampsia can reduce the incidence of preterm pre\u2010eclampsia. However, no previous studies have evaluated the impact of routine first\u2010trimester combined screening for pre\u2010eclampsia with placental growth factor after being implemented in the clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>This was a multicenter cohort study conducted in eight different maternities across Spain. Participants in the reference group were prospectively recruited between October 2015 and September 2017. Participants in the study group were retrospectively recruited between March 2019 and May 2021. Pre\u2010eclampsia risk was calculated between 11<jats:sup>+0<\/jats:sup> and 13<jats:sup>+6<\/jats:sup>\u2009weeks using the Gaussian algorithm combining maternal characteristics, mean arterial pressure, uterine arteries pulsatility index, pregnancy\u2010associated plasma protein\u2010A and placental growth factor. Patients with a risk greater than 1\/170 were prescribed daily salicylic acid 150\u2009mg until 36\u2009weeks. Patients in the reference group did not receive salicylic acid during gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant reduction was observed in preterm pre\u2010eclampsia (OR 0.47; 95% CI: 0.30\u20130.73), early\u2010onset (&lt;34\u2009weeks) pre\u2010eclampsia (OR 0.35; 95% CI: 0.16\u20130.77), preterm small for gestational age newborn (OR 0.57; 95% CI: 0.40\u20130.82), spontaneous preterm birth (OR 0.72; 95% CI: 0.57\u20130.90), and admission to intensive care unit (OR 0.55; 95% CI: 0.37\u20130.81). A greater treatment adherence resulted in a significant reduction in adverse outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Routine first\u2010trimester screening for pre\u2010eclampsia with placental growth factor leads to a reduction in preterm pre\u2010eclampsia and other pregnancy complications. Aspirin treatment compliance has a great impact on the effectiveness of this screening program.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14687","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T02:20:01Z","timestamp":1697077201000},"page":"1711-1718","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical effectiveness of routine first\u2010trimester combined screening for pre\u2010eclampsia in Spain with the addition of placental growth factor"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2415-1626","authenticated-orcid":false,"given":"Pablo","family":"Garcia\u2010Manau","sequence":"first","affiliation":[{"name":"Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Department of Obstetrics Vall d'Hebron Barcelona Hospital Campus  Barcelona 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