{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:09:43Z","timestamp":1775693383040,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Primary human papilloma virus (HPV) screening to detect cervical cancer and dysplastic lesions was implemented in Region Sk\u00e5ne 2017 for women aged 30\u201370. The aim of this study was to characterize the screening history of women diagnosed with cervical cancer to evaluate the performance of the screening program, as well as to assess the cancer treatments given and shortcomings in the follow\u2010up of women with cervical dysplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>We performed a quality assurance audit. The data was collected from the National Cervical Cancer Prevention Registry, Region Sk\u00e5ne Labmedicin database and the Melior Journal system in 2017\u20132020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 247 women diagnosed with invasive cervical cancer in Region Sk\u00e5ne in 2017\u20132020. Of these, 35 (14.2%) had a screening history over at least two screening rounds before diagnosis. There were 25 (10.1%) women diagnosed with cervical cancer in between screening intervals, i.e., interval cancer. The most common screening history in women with cervical cancer was irregular screening (143, 57.9%), followed by women being above screening age (44, 17.8%). HPV was detected in 96% of the cases, either in cervical cytology or in the tumor tissue. The screening program detected the disease in 96 (38.9%) of the patients, 149 (60.3%) were diagnosed through symptoms and two (0.80%) as a result of incidental findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The most powerful tool in the prevention of cervical cancer is screening program attendance. Prolongation with HPV screening among elderly women will also reduce the incidence of cervical cancer. Today, such cancers are usually discovered when symptoms appear.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14691","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T04:57:26Z","timestamp":1697086646000},"page":"129-137","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cervical cancer in Region Sk\u00e5ne, Sweden 2017\u20132020 after the implementation of primary <scp>HPV<\/scp> screening: A quality assurance audit"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4206-7337","authenticated-orcid":false,"given":"Caroline","family":"Hellsten","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sk\u00e5ne University Hospital, Department of Clinical Science Lund Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Holmberg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sk\u00e5ne University Hospital, Department of Clinical Science Lund Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennica","family":"Astrom","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sk\u00e5ne University Hospital, Department of Clinical Science Lund Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6293-7286","authenticated-orcid":false,"given":"Ola","family":"Forslund","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Lund University  Lund Sweden"},{"name":"Clinical Microbiology, Infection Prevention and Control, Office for Medical Services  Region Sk\u00e5ne Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christer","family":"Borgfeldt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sk\u00e5ne University Hospital, Department of Clinical Science Lund Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,10]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16674-9"},{"issue":"3","key":"e_1_2_13_3_1","first-page":"S3\/1","article-title":"Chapter 1: HPV in the etiology of human cancer","volume":"24","author":"Munoz N","year":"2006","journal-title":"Vaccine"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22357"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21953"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jncimonographs.a003477"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000515912"},{"key":"e_1_2_13_8_1","unstructured":"NORDCAN.Incidence and mortality in cervical cancer in Sweden 1967\u20132020."},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13313"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn099"},{"key":"e_1_2_13_11_1","unstructured":"Nationellt Kvalitetsregister f\u00f6r Cervixcancerprevention NKCx. Available from:http:\/\/www.nkcx.se\/"},{"key":"e_1_2_13_12_1","unstructured":"WHO.Human Papillomavirus (HPV) and Cervical Cancer. [cited 2022 December]. 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Activity Report and Annual Report 2020 with Data up to and Including 2019.]","author":"Dillner J","year":"2020"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-12-0162"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.14691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T13:24:23Z","timestamp":1748352263000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.14691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,10]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/aogs.14691"],"URL":"https:\/\/doi.org\/10.1111\/aogs.14691","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,10]]},"assertion":[{"value":"2023-06-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}