{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:07:01Z","timestamp":1791360421270,"version":"4.3.1"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017017","name":"Statens beredning f\u00f6r medicinsk och social utv\u00e4rdering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017017","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hyperemesis gravidarum affects 0.3%\u20133% of pregnant women each year and is the leading cause of hospitalization in early pregnancy. Previous systematic reviews of available treatments have found a lack of consistent evidence, and few studies of high quality. Since 2016, no systematic review has been conducted and an up\u2010to date review is requested. In a recent James Lind Alliance collaboration, it was clear that research on effective treatments is a high priority for both patients and clinicians.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>Searches without time limits were performed in the AMED, CINAHL, Cochrane Library, EMBASE, Medline, PsycINFO, and Scopus databases until June 26, 2023. Studies published before October 1, 2014 were identified from the review by O'Donnell et\u00a0al., 2016. Selection criteria were randomized clinical trials and non\u2010randomized studies of interventions comparing treatment of hyperemesis gravidarum with another treatment or placebo. Outcome variables included were: degree of nausea; vomiting; inability to tolerate oral fluids or food; hospital treatment; health\u2010related quality of life, small\u2010for\u2010gestational\u2010age infant; and preterm birth. Abstracts and full texts were screened, and risk of bias of the studies was assessed independently by two authors. Synthesis without meta\u2010analysis was performed, and certainty of evidence was assessed using the GRADE approach. PROSPERO (CRD42022303150).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty treatments were included in 25 studies with low or moderate risk of bias. The certainty of evidence was very low for all treatments except for acupressure in addition to standard care, which showed a possible moderate decrease in nausea and vomiting, with low certainty of evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Several scientific knowledge gaps were identified. Studies on treatments for hyperemesis gravidarum are few, and the certainty of evidence for different treatments is either low or very low. To establish more robust evidence, it is essential to use validated scoring systems, the recently established diagnostic criteria, clear descriptions and measurements of core outcomes and to perform larger studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.14706","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T23:58:11Z","timestamp":1698451091000},"page":"13-29","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Treatments for hyperemesis gravidarum: A systematic review"],"prefix":"10.1111","volume":"103","author":[{"given":"Marie\u2010Therese","family":"Vinnars","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Obstetrics and Gynecology Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6674-3849","authenticated-orcid":false,"given":"Maria","family":"Forslund","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Institute of Clinical Sciences, Sahlgrenska Akademin, University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ing\u2010Marie","family":"Claesson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, and Department of Clinical and Experimental Medicine Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annicka","family":"Hedman","sequence":"additional","affiliation":[{"name":"Swedish Agency for Health Technology Assessment and Assessment of Social Services  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Peira","sequence":"additional","affiliation":[{"name":"Swedish Agency for Health Technology Assessment and Assessment of Social Services  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Olofsson","sequence":"additional","affiliation":[{"name":"Swedish Agency for Health Technology Assessment and Assessment of Social Services  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Wernersson","sequence":"additional","affiliation":[{"name":"Swedish Agency for Health Technology Assessment and Assessment of Social Services  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9718-754X","authenticated-orcid":false,"given":"Hanna","family":"Ulfsdottir","sequence":"additional","affiliation":[{"name":"Division of Reproductive Health, Department of Women's and Children's Health Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0110-3"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjom.2018.26.2.109"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2007.08.009"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.03.052"},{"key":"e_1_2_11_6_1","first-page":"e149","article-title":"Economic burden of nausea and vomiting of pregnancy in the USA","volume":"20","author":"Piwko C","year":"2013","journal-title":"J Popul Ther Clin Pharmacol"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000477853"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta20740"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2021.09.004"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15272"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-041254"},{"issue":"5","key":"e_1_2_11_12_1","first-page":"CD010607","article-title":"Interventions for treating hyperemesis gravidarum","volume":"2016","author":"Boelig RC","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-021-01626-4"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16172"},{"key":"e_1_2_11_15_1","volume-title":"The EndNote Team. 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