{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T23:14:41Z","timestamp":1772493281299,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020586","name":"storbyuniversitetet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Labor induction rates have increased over the last decades, and in many high\u2010income countries, more than one in four labors are induced. Outpatient management of labor induction has been suggested in low\u2010risk pregnancies to improve women's birth experiences while also promoting a more efficient use of healthcare resources. The primary aim of this paper was to assess the proportion of women in a historical cohort that would have been eligible for outpatient labor induction with oral misoprostol. Second, we wanted to report safety outcomes and assess efficacy outcomes for mothers and infants in pregnancies that met the criteria for outpatient care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Criteria for outpatient labor induction with oral misoprostol were applied to a historical cohort of women with induction of labor at two Norwegian tertiary hospitals in the period January 1, through July 31, 2021. The criteria included low\u2010risk women with an unscarred uterus expecting a healthy, singleton baby in cephalic position at term. The primary outcome was the proportion of women eligible for outpatient labor induction. Secondary outcomes included reasons for ineligibility and, for eligible women, safety and efficacy outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 29.7% of the 1320 women who underwent labor induction in a singleton term pregnancy met the criteria for outpatient labor induction. We identified two serious adverse events that potentially could have occurred outside the hospital if the women had received outpatient care. The mean duration from initiation of labor induction to administration of the last misoprostol was 22.4\u2009h. One in 14 multiparous women gave birth within 3 h after the last misoprostol dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this historical cohort, three in ten women met the criteria for outpatient management of labor induction with oral misoprostol. Serious adverse events were rare. The average time span from the initiation of labor induction to the last misoprostol was nearly 24\u2009h. This suggests a potential for low\u2010risk women with an induced labor to spend a substantial period of time at home before labor onset. However, larger studies testing or evaluating labor induction with oral misoprostol as an outpatient procedure are needed to draw conclusions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14799","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T05:39:54Z","timestamp":1710913194000},"page":"1101-1111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Outpatient labor induction\u2014Exploring future potential by assessing eligibility in a historical cohort"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6206-3854","authenticated-orcid":false,"given":"Kjersti Engen","family":"Marsdal","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences, Department of Nursing and Health Promotion Oslo Metropolitan University  Oslo Norway"},{"name":"Division of Obstetrics and Gynecology Oslo University Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8998-4285","authenticated-orcid":false,"given":"Ingvil Krarup","family":"S\u00f8rbye","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology Oslo University Hospital  Oslo Norway"},{"name":"Institute of Clinical Medicine, Faculty of Medicine University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stine","family":"Bernitz","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Department of Nursing and Health Promotion Oslo Metropolitan University  Oslo Norway"},{"name":"Department of Obstetrics and Gynecology \u00d8stfold Hospital Trust  Gr\u00e5lum Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranveig Elise T.","family":"Sve","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology Oslo University Hospital  Oslo Norway"},{"name":"Department of Nursing and Social Sciences Institute of Nursing and Health Sciences, University of South\u2010Eastern Norway  Kongsberg Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine","family":"Ask","sequence":"additional","affiliation":[{"name":"Department of Nursing and Social Sciences Institute of Nursing and Health Sciences, University of South\u2010Eastern Norway  Kongsberg Norway"},{"name":"Department of Obstetrics Drammen Hospital  Drammen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirjam","family":"Lukasse","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Department of Nursing and Health Promotion Oslo Metropolitan University  Oslo Norway"},{"name":"Department of Nursing and Social Sciences Institute of Nursing and Health Sciences, University of South\u2010Eastern Norway  Kongsberg Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/NMC.0000000000000824"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-060161"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-032815"},{"key":"e_1_2_12_5_1","unstructured":"Medical Birth Registry of Norway. 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