{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:33:27Z","timestamp":1792708407817,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF18OC0054457"],"award-info":[{"award-number":["NNF18OC0054457"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Maternal demographics have evolved, and more women than ever enter pregnancy with preexisting comorbidity and with potentially complex medication exposure, including polypharmacy (concomitant intake of multiple medications). This study aims to describe the evolution of medication use in pregnancy in Denmark from 1998 to 2018 with special focus on polypharmacy, patterns of use, and underlying demographics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>A Danish nationwide historical registry study based on all clinically recognized pregnancies with a gestation \u226510\u2009weeks between 1998 and 2018. Medication use was estimated by redemption of prescriptions during pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among a total of 1\u2009402\u2009327 clinically recognized pregnancies, redemption of at least one prescription medication during pregnancy increased from 56.9% in 1998 to 63.3% in 2018, coinciding with an increased use of polypharmacy (from 24.8% in 1998 to 35.2% in 2018). The prevalence of pregnant women who used medications for chronic conditions increased more than the prevalence of women treated for occasional or short\u2010time conditions. Redemption of one or multiple prescription medications during pregnancy was mostly seen among pregnant women \u226535\u2009years of age. However, pregnant women &lt;25\u2009years old exhibited the largest increase in medication use during the study period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Medication use in general, and polypharmacy in particular, increased from 1998 to 2008, possibly as the result of an increased prevalence of pregnant women with chronic conditions requiring pharmacological treatment. Notably, a marked maternal age\u2010based discrepancy in usage pattern was observed, highlighting the need for further research in this area. The rise in the prevalence of polypharmacy during pregnancy underscores the need for pharmacovigilance to monitor adverse effects. Future studies should investigate the patterns of polypharmacy and the accompanying maternal and fetal risks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.14805","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T02:38:48Z","timestamp":1710556728000},"page":"1210-1223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Use of medication in pregnancy on the rise: Study on 1.4\u00a0million Danish pregnancies from 1998 to 2018"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7180-3180","authenticated-orcid":false,"given":"Mette \u00d8stergaard","family":"Thunbo","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9329-7905","authenticated-orcid":false,"given":"Julie Hauer","family":"Vendelbo","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0769-2922","authenticated-orcid":false,"given":"Daniel R.","family":"Witte","sequence":"additional","affiliation":[{"name":"Department of Public Health Aarhus University  Aarhus Denmark"},{"name":"Steno Diabetes Center Aarhus Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8765-8443","authenticated-orcid":false,"given":"Agnete","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Biomedicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6726-1991","authenticated-orcid":false,"given":"Lars Henning","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Biomedicine Aarhus University  Aarhus Denmark"},{"name":"Department of Obstetrics and Gynecology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,15]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128312"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02722-5"},{"issue":"51","key":"e_1_2_13_4_1","first-page":"e1","article-title":"Medication use during pregnancy, with particular focus on prescription drugs: 1976\u20132008","volume":"205","author":"Mitchell AA","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S17747"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2004.04.003"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1704559"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002280050608"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2184"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmacy5020021"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1269"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S16305"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.223"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-004365"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002579"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-004-0775-7"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.4314\/ahs.v20i3.24"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-003-0584-4"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0322-7"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semperi.2020.151221"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-006-0119-x"},{"key":"e_1_2_13_22_1","volume-title":"International Statistical Classification of Diseases and Related Health Problems","author":"World Health Organization","year":"2015"},{"key":"e_1_2_13_23_1","unstructured":"Sundhedsdatastyrelsen.Klassifikation af sygdomme.2021.https:\/\/sundhedsdatastyrelsen.dk\/da\/rammer\u2010og\u2010retningslinjer\/om\u2010klassifikationer\/sks\u2010klassifikationer\/klassifikation\u2010sygdomme"},{"key":"e_1_2_13_24_1","unstructured":"The Nordic Medico\u2010Statistical Committee (NOMESCO).NOMESCO classification of surgical procedures (NCSP).2011."},{"key":"e_1_2_13_25_1","unstructured":"Sundhedsdatastyrelsen.Klassifikation af operationer.2021.https:\/\/sundhedsdatastyrelsen.dk\/da\/rammer\u2010og\u2010retningslinjer\/om\u2010klassifikationer\/sks\u2010klassifikationer\/klassifikation\u2010operationer"},{"key":"e_1_2_13_26_1","first-page":"441","article-title":"The Danish Civil Registration System. A cohort of eight million persons","volume":"53","author":"Pedersen CB","year":"2006","journal-title":"Dan Med Bull"},{"key":"e_1_2_13_27_1","volume-title":"Anatomical Therapeutic Chemical (ATC) classification","author":"World Health Organization","year":"2023"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.00927.x"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.08.045"},{"key":"e_1_2_13_30_1","unstructured":"Danish Health Authority.Anbefalinger for svangreomsorgen.2022."},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)34173-1"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-022-04442-3"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4755-11-37"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62071-1"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2008.03102.x"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2011.11.025"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-021-00553-7"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13396"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.4054\/DemRes.2009.21.22"},{"key":"e_1_2_13_40_1","unstructured":"World Health Organization.Abortions per 1000 live births.2023.https:\/\/gateway.euro.who.int\/en\/indicators\/hfa_586\u20107010\u2010abortions\u2010per\u20101000\u2010live\u2010births\/visualizations\/#id=19681"},{"key":"e_1_2_13_41_1","unstructured":"Dansk Selskab for Obstetrik og Gyn\u00e6kologi.Graviditet efter termin.2009."}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.14805","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T15:05:15Z","timestamp":1744297515000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.14805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,15]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/aogs.14805"],"URL":"https:\/\/doi.org\/10.1111\/aogs.14805","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,15]]},"assertion":[{"value":"2023-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}