{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T04:01:58Z","timestamp":1743998518251,"version":"3.40.3"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001275","name":"Oak Foundation","doi-asserted-by":"publisher","award":["OCAY\u201018\u2010774\u2010OFIL"],"award-info":[{"award-number":["OCAY\u201018\u2010774\u2010OFIL"]}],"id":[{"id":"10.13039\/100001275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Sufficient levels of vitamin D have been associated with higher chances for both clinical pregnancy and live birth among women undergoing assisted reproductive techniques, whereas low levels of maternal vitamin D have been associated with preeclampsia and late miscarriage. In Denmark, subgroups at risk for low vitamin D levels, including neonates and toddlers, are recommended to use supplementation. The aim was to study the level of vitamin D<jats:sub>3<\/jats:sub> among neonates born after in\u00a0vitro fertilization compared with neonates from the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>In this cohort study a random sample of 1326 neonates representing the general population and 1200 neonates conceived by in\u00a0vitro fertilization born in Denmark from 1995 to 2002 were identified from registries covering the whole Danish population. Information on use of assisted reproduction was collected from the Danish In\u00a0Vitro Fertilization register, ICD\u201010 code: DZ358F. 25\u2010Hydroxyvitamin D was measured from dried blood spots routinely collected by heel prick 48\u201372\u2009h after birth and corrected according to the hematocrit fraction for capillary blood of neonates. Linear regression analysis was performed, both crude and adjusted, for predefined putative confounders, identified through directed acyclic graphs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Vitamin D<jats:sub>3<\/jats:sub> analysis could be performed from a total of 1105 neonates from the general population and 1072 neonates conceived by in\u00a0vitro fertilization that were subsequently included in the study. The median vitamin D<jats:sub>3<\/jats:sub> was 24.0\u2009nmol\/L (interquartile range [IQR] 14.1\u201339.3) and 33.0\u2009nmol\/L (IQR 21.3\u201348.8) among neonates from the general population and neonates conceived by in\u00a0vitro fertilization, respectively. The adjusted mean difference between neonates from the general population and those conceived by in\u00a0vitro fertilization was 6.1\u2009nmol\/L (95% confidence interval 4.1\u20138.1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this study, children born after in\u00a0vitro fertilization have a higher vitamin D<jats:sub>3<\/jats:sub> than a random sample of neonates in Denmark.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14819","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T05:39:48Z","timestamp":1713505188000},"page":"1329-1338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vitamin <scp>D<sub>3<\/sub><\/scp> among neonates born after in\u00a0vitro fertilization compared with neonates from the general population"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9867-1416","authenticated-orcid":false,"given":"Karen Christina","family":"Walker","sequence":"first","affiliation":[{"name":"Research Unit for Dietary Studies The Parker Institute, Bispebjerg and Frederiksberg Hospital  Frederiksberg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofie Gry","family":"Pristed","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aalborg University Hospital  Aalborg Denmark"},{"name":"Program of Biomedical Laboratory Science University College of Northern Denmark  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3070-782X","authenticated-orcid":false,"given":"Fanney","family":"Thorsteinsdottir","sequence":"additional","affiliation":[{"name":"Research Unit for Dietary Studies The Parker Institute, Bispebjerg and Frederiksberg Hospital  Frederiksberg Denmark"},{"name":"The Department of Public Health, Section for General Practice University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3114-4715","authenticated-orcid":false,"given":"Ina Olmer","family":"Specht","sequence":"additional","affiliation":[{"name":"Research Unit for Dietary Studies The Parker Institute, Bispebjerg and Frederiksberg Hospital  Frederiksberg Denmark"},{"name":"The Department of Public Health, Section for General Practice University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arieh","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department for Congenital Disorders, Danish Center for Neonatal Screening Statens Serum Institute  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6809-4504","authenticated-orcid":false,"given":"Berit Lilienthal","family":"Heitmann","sequence":"additional","affiliation":[{"name":"Research Unit for Dietary Studies The Parker Institute, Bispebjerg and Frederiksberg Hospital  Frederiksberg Denmark"},{"name":"The Department of Public Health, Section for General Practice University of Copenhagen  Copenhagen Denmark"},{"name":"The Boden Institute of Obesity, Nutrition, Exercise &amp; Eating Disorders The University of Sydney  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3868-106X","authenticated-orcid":false,"given":"Ulrik Schi\u00f8ler","family":"Kesmodel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Obstetrics and Gynecology Herlev University Hospital  Herlev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2018.12.001"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmv016"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0984"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2012.18"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443397"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.10.008"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0026-4806.18.05946-3"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12978-019-0769-7"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu156"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.05.040"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex326"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0718"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-017-2476-0"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2704"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089907"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eprac.2023.01.005"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/88.2.520S"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2018-0422"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.013"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810387965"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-021-00742-8"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-018-0356-1"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2009.02.005"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2010.01105.x"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2017.07.018"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyz032"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-016-0281-5"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12982-017-0062-6"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1983.tb09822.x"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des176"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem398"},{"key":"e_1_2_13_34_1","first-page":"103","volume-title":"Nordiska N\u00e4ringsrekommendationer 1996. 3. 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