{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:00:57Z","timestamp":1788246057475,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21K10438"],"award-info":[{"award-number":["JP21K10438"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP17km0105001"],"award-info":[{"award-number":["JP17km0105001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19gk0110039"],"award-info":[{"award-number":["JP19gk0110039"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21tm0124005"],"award-info":[{"award-number":["JP21tm0124005"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJSP2114"],"award-info":[{"award-number":["JPMJSP2114"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Developmental delay at an early age indicates the probability of continued problems after school age. Hypertensive disorders of pregnancy (HDP) are associated with developmental delays in offspring, with inconsistent outcomes. Neonatal outcomes vary according to HDP exposure and are relevant to development in later years. Here we aimed to clarify the relationship between HDP and developmental delay in offspring and whether neonatal outcomes mediate this association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>We used data from 5934 mother\u2013child pairs from the Tohoku Medical Megabank Project Birth and Three\u2010Generation Cohort Study, a prospective cohort study conducted in Japan between July 2013 and March 2017. The Ages and Stages Questionnaires, third edition, at 24 and 42\u2009months of age, measured developmental delay in five areas. We performed multivariate quasi\u2010Poisson regression and causal mediation analysis by neonatal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At 24\u2009months of age, compared to offspring born from normotensive mothers, offspring born from HDP\u2010affected mothers were more likely to experience developmental delay (risk ratio [RR] 1.29, 95% confidence interval [CI]: 1.09\u20131.52) in the areas of communication (RR 1.21, 95% CI: 1.00\u20131.45) and personal\u2010social (RR 1.15, 95% CI: 1.03\u20131.28). This association was mediated by neonatal outcomes: preterm birth, neonatal asphyxia, NICU admission, and neonatal small head circumference. No association was observed between HDP and developmental delay at 42\u2009months of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Exposure to HDP during fetal life is associated with offspring developmental delay. This association is partly mediated by neonatal outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.14820","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:39:52Z","timestamp":1709858392000},"page":"1192-1200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hypertensive disorders of pregnancy, neonatal outcomes and offspring developmental delay in Japan: The Tohoku Medical Megabank Project Birth and Three\u2010Generation Cohort Study"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7834-1388","authenticated-orcid":false,"given":"Geng","family":"Chen","sequence":"first","affiliation":[{"name":"Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2884-0023","authenticated-orcid":false,"given":"Mami","family":"Ishikuro","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine  Sendai Japan"},{"name":"Tohoku Medical Megabank Organization, Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Ohseto","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Murakami","sequence":"additional","affiliation":[{"name":"Tohoku Medical Megabank Organization, Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoi","family":"Noda","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine  Sendai Japan"},{"name":"Tohoku Medical Megabank Organization, Tohoku University  Sendai Japan"},{"name":"Tohoku University Hospital  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genki","family":"Shinoda","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine  Sendai Japan"},{"name":"Tohoku Medical Megabank Organization, Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatsugu","family":"Orui","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine  Sendai Japan"},{"name":"Tohoku Medical Megabank Organization, Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Obara","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine  Sendai Japan"},{"name":"Tohoku Medical Megabank Organization, Tohoku University  Sendai Japan"},{"name":"Tohoku University Hospital  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Kuriyama","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine  Sendai Japan"},{"name":"Tohoku Medical Megabank Organization, Tohoku University  Sendai Japan"},{"name":"International Research Institute of Disaster Science, Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"e_1_2_14_2_1","unstructured":"Ministry of Health Labour and Welfare.Overview of Survey on Difficulty in Life (National Survey of Disabled Children and People at Home).2016. Available online at: (Accessed November 25 2022)https:\/\/www.mhlw.go.jp\/toukei\/list\/dl\/seikatsu_chousa_b_h28.pdf"},{"key":"e_1_2_14_3_1","unstructured":"Statistics Bureau of Japan.Population Estimates (as of October 1.2016). 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