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Analyzing the endometrial transcriptome analysis may reveal the underlying processes and could help in guiding prognosis and using targeted interventions for infertility. This exploratory study investigated whether the endometrial transcriptome profile was associated with short\u2010term or long\u2010term implantation outcomes (ie success or failure).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Mid\u2010luteal phase endometrial biopsies of 107 infertile women with one full failed IVF\/ICSI cycle, obtained within an endometrial scratching trial, were subjected to RNA\u2010sequencing and differentially expressed genes analysis with covariate adjustment (age, body mass index, luteinizing hormone [LH]\u2010day). Endometrial transcriptomes were compared between implantation failure and success groups in the short term (after the second fresh IVF\/ICSI cycle) and long term (including all fresh and frozen cycles within 12\u2009months). The short\u2010term analysis included 85\/107 women (33 ongoing pregnancy vs 52 no pregnancy), excluding 22\/107 women. The long\u2010term analysis included 46\/107 women (23 \u2018fertile\u2019 group, ie infertile women with a live birth after \u22643 embryos transferred vs\u200923 recurrent implantation failure group, ie no live birth after \u22653 good quality embryos transferred), excluding 61\/107 women not fitting these categories. As both analyses drew from the same pool of 107 samples, there was some sample overlap. Additionally, cell type enrichment scores and endometrial receptivity were analyzed, and an endometrial development pseudo\u2010timeline was constructed to estimate transcriptomic deviations from the optimum receptivity day (LH\u2009+\u20097), denoted as \u0394WOI (window of implantation).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significantly differentially expressed genes between implantation failure and success groups in either the short\u2010term or long\u2010term analyses. Principal component analysis initially showed two clusters in the long\u2010term analysis, unrelated to clinical phenotype and no longer distinct following covariate adjustment. Cell type enrichment scores did not differ significantly between groups in both analyses. However, endometrial receptivity analysis demonstrated a potentially significant displacement of the WOI in the non\u2010pregnant group compared with the ongoing pregnant group in the short\u2010term analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No distinct endometrial transcriptome profile was associated with either implantation failure or success in infertile women. However, there may be differences in the extent to which the WOI is displaced.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14822","type":"journal-article","created":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T06:13:30Z","timestamp":1711174410000},"page":"1348-1365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The endometrial transcriptome of infertile women with and without implantation failure"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3542-6215","authenticated-orcid":false,"given":"Bich Ngoc","family":"Bui","sequence":"first","affiliation":[{"name":"Department of Gynecology and Reproductive Medicine University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktorija","family":"Kukushkina","sequence":"additional","affiliation":[{"name":"Estonian Genome Center, Institute of Genomics University of 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