{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T15:11:08Z","timestamp":1793373068018,"version":"4.5.0"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>To assess the rate of change in soluble fms\u2010like tyrosine kinase\u20101\/placental growth factor (sFlt\u20101\/PlGF) ratio and PlGF levels per week compared to a single sFlt\u20101\/PlGF ratio or PlGF level to predict preterm birth for pregnancies complicated by fetal growth restriction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A prospective cohort study of pregnancies complicated by isolated fetal growth restriction. Maternal serum PlGF levels and the sFlt\u20101\/PlGF ratio were measured at 4\u2010weekly intervals from recruitment to delivery. We investigated the utility of PlGF levels, sFlt\u20101\/PlGF ratio, change in PlGF levels per week or sFlt\u20101\/PlGF ratio per week. Cox\u2010proportional hazard models and Harrell's C concordance statistic were used to evaluate the effect of biomarkers on time to preterm birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total study cohort was 158 pregnancies comprising 91 (57.6%) with fetal growth restriction and 67 (42.4%) with appropriate for gestational age controls. In the fetal growth restriction cohort, sFlt\u20101\/PlGF ratio and PlGF levels significantly affected time to preterm birth (Harrell's C: 0.85\u20130.76). The rate of increase per week of the sFlt\u20101\/PlGF ratio (hazard ratio [HR] 3.91, 95% confidence interval [CI]: 1.39\u201310.99, <jats:italic>p<\/jats:italic>\u2009=\u20090.01, Harrell's C: 0.74) was positively associated with preterm birth but change in PlGF levels per week was not (HR 0.65, 95% CI: 0.25\u20131.67, <jats:italic>p<\/jats:italic>\u2009=\u20090.37, Harrell's C: 0.68).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both a high sFlt\u20101\/PlGF ratio and low PlGF levels are predictive of preterm birth in women with fetal growth restriction. Although the rate of increase of the sFlt\u20101\/PlGF ratio predicts preterm birth, it is not superior to either a single elevated sFlt\u20101\/PlGF ratio or low PlGF level.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14831","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T09:54:45Z","timestamp":1710410085000},"page":"1112-1119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prediction of preterm birth in women with fetal growth restriction \u2013 Is the weekly change in <scp>sFlt<\/scp>\u20101\/<scp>PlGF<\/scp> ratio or <scp>PlGF<\/scp> levels useful?"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8585-2357","authenticated-orcid":false,"given":"Jesrine","family":"Hong","sequence":"first","affiliation":[{"name":"Mater Research Institute University of Queensland  South Brisbane Queensland Australia"},{"name":"Faculty of Medicine The University of Queensland  Herston Queensland Australia"},{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Universiti Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylie","family":"Crawford","sequence":"additional","affiliation":[{"name":"Mater Research Institute University of Queensland  South Brisbane Queensland Australia"},{"name":"Faculty of Medicine The University of Queensland  Herston Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Cavanagh","sequence":"additional","affiliation":[{"name":"Mater Research Institute University of Queensland  South Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki","family":"Clifton","sequence":"additional","affiliation":[{"name":"Mater Research Institute University of Queensland  South Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0832-4811","authenticated-orcid":false,"given":"Sailesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Mater Research Institute University of Queensland  South Brisbane Queensland Australia"},{"name":"Faculty of Medicine The University of Queensland  Herston Queensland Australia"},{"name":"NHMRC Centre for Research Excellence in Stillbirth, Mater Research Institute University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13522"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22134"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.05.010"},{"key":"e_1_2_14_5_1","unstructured":"Royal College of Obstetricians & Gynaecologists (RCOG).Small\u2010for\u2010Gestational\u2010Age Fetus Investigation and Management (Green\u2010top Guideline No. 31) 2014. 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