{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T20:57:41Z","timestamp":1770497861151,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>This study aimed to identify whether microbial invasion of the amniotic cavity and\/or intra\u2010amniotic inflammation in women with late preterm prelabor rupture of membranes (PPROM) was associated with changes in concentrations of soluble fms\u2010like tyrosine kinase\u20101 (sFlt\u20101), placental growth factor (PlGF) and its ratio in maternal serum, and whether placental features consistent with maternal vascular malperfusion further affect their concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>This historical study included 154 women with singleton pregnancies complicated by PPROM between gestational ages 34+0 and 36+6\u2009weeks. Transabdominal amniocentesis was performed as part of standard clinical management to evaluate the intra\u2010amniotic environment. Women were categorized into two subgroups based on the presence of microorganisms and\/or their nucleic acids in amniotic fluid (determined by culturing and molecular biology method) and intra\u2010amniotic inflammation (by amniotic fluid interleukin\u20106 concentration evaluation): (1) those with the presence of microorganisms and\/or inflammation (at least one present) and (2) those with negative amniotic fluid for infection\/inflammation (absence of both). Concentrations of sFlt\u20101 and PlGF were assessed using the Elecsys\u00ae sFlt\u20101 and Elecsys\u00ae PlGF immunoassays and converted into multiples of medians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women with the presence of microorganisms and\/or inflammation in amniotic fluid had lower serum concentrations of sFlt\u20101 and sFlt\u20101\/PlGF ratios and higher concentrations of PlGF compared with those with negative amniotic fluid. (sFlt\u20101: presence: median 1.0 multiples of the median (MoM), vs negative: median: 1.5 MoM, <jats:italic>P<\/jats:italic>\u2009=\u20090.003; PlGF: presence: median 0.7 MoM, vs negative: median 0.4 MoM, <jats:italic>P<\/jats:italic>\u2009=\u20090.02; sFlt\u20101\/PlGF: presence: median 8.9 vs negative 25.0, <jats:italic>P<\/jats:italic>\u2009=\u20090.001). Higher serum concentrations of sFlt\u20101 and sFlt\u20101\/PlGF ratios as well as lower concentrations of PlGF were found in the subsets of women with maternal vascular malperfusion than in those without maternal vascular malperfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among women experiencing late PPROM, angiogenic imbalance in maternal serum is primarily observed in those without both microbial invasion of the amniotic cavity and intra\u2010amniotic inflammation. Additionally, there is an association between angiogenic imbalance and the presence of maternal vascular malperfusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14833","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T10:15:16Z","timestamp":1711016116000},"page":"1120-1131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Angiogenic imbalance in pregnancies with preterm prelabor rupture of membranes between 34 and 37\u2009weeks of gestation"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9858-7900","authenticated-orcid":false,"given":"Marian","family":"Kacerovsky","sequence":"first","affiliation":[{"name":"Biomedical Research Center University Hospital Hradec Kralove  Hradec Kralove Czech Republic"},{"name":"Department of Obstetrics and Gynecology Hospital Most  Usti nad Labem Czech 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