{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:12:58Z","timestamp":1787062378876,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:00:00Z","timestamp":1712620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Vasa previa (VP), defined as unprotected fetal vessels traversing the membranes over the cervix, is associated with a high perinatal mortality when undiagnosed prenatally. Conversely, prenatal diagnosis with ultrasound and cesarean delivery before the membranes rupture is associated with excellent outcomes. However, controversy exists regarding screening for VP. In the UK, routine screening for VP is not recommended. The objective of this study was to report the incidence of VP and our experience in the detection of VP with a universal screening protocol at the time of the second\u2010trimester fetal anomaly scan with third\u2010trimester confirmation in an unselected population of pregnancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>We performed a single\u2010center historical cohort study of all pregnant women who underwent routine second\u2010trimester anomaly screening scans at West Middlesex University Hospital, London, UK, between 2012 and 2016. Over 5\u2009years, every patient undergoing routine anomaly screening was evaluated for VP using a systematic protocol during their 20\u2010week anomaly scan. Suspected cases of VP were rescanned in the third trimester by specialist sonographers with an interest in VP. The primary outcomes were the incidence and detection of VP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the study period, 24\u2009690 anatomy scans were performed. A total of 64 patients were identified as having potential VP at the second\u2010trimester anomaly screening scan, of which 19 were confirmed by the specialist sonographer in the third trimester and at delivery. The screen positive rate was 0.26% (95% confidence interval [CI] 0.20%\u20130.32%). VP at birth was found in 19\/24690 births (1:1299 [95% CI: 1:832\u20131:2030] births). Universal screening for VP using our protocol had a sensitivity of 100% and a specificity of 99.78% (95% CI: 99.72%\u201399.84%). The false\u2010positive rate of the second\u2010trimester screen was 0.18% (95% CI: 0.13\u20130.24). There were no false positives or false negatives at delivery. Of the 19 patients with confirmed VP, 17 had scheduled cesarean deliveries, and two required emergency deliveries due to antepartum hemorrhage. One baby died, giving a perinatal mortality of 5%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>VP complicates approximately 1:1300 pregnancies. Routine screening for VP yielded a 100% detection rate. We suggest the inclusion of structured VP assessment in standard fetal anomaly screening programs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.14839","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T01:40:23Z","timestamp":1712713223000},"page":"1466-1473","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Incorporation of vasa previa screening into a routine anomaly scan: A single center cohort study"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2017-9223","authenticated-orcid":false,"given":"Millicent","family":"Nwandison","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Chelsea and Westminster NHS Foundation Trust Hospital West Middlesex University Hospital  London 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UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"De\u2010Rosnay","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Chelsea and Westminster NHS Foundation Trust Hospital West Middlesex University Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Sebire","sequence":"additional","affiliation":[{"name":"NIHR Great Ormond Street Hospital Biomedical Research Center Great Ormond Street Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Nyberg","sequence":"additional","affiliation":[{"name":"Kensington Medical Chambers  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1509-0152","authenticated-orcid":false,"given":"Yinka","family":"Oyelese","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and 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