{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:46:00Z","timestamp":1784547960997,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The decision to terminate a pregnancy due to fetal anomalies can have a significant emotional impact, especially in second\u2010trimester terminations. Previous studies on the psychological consequences of pregnancy termination have had limitations, and little is known about the outcomes for partners and the impact of fetal donation. Therefore, we aimed to investigate the psychological effects of second\u2010trimester pregnancy termination and identify factors associated with outcomes in both women and men, including donation of fetal remains to science.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A longitudinal cohort study was conducted at the Amsterdam UMC in the Netherlands, involving women and partners who underwent termination at or before 23\u2009weeks and 6\u2009days of gestation. Questionnaires were administered at termination, 6\u2009weeks, and 4\u2009months after. We utilized validated questionnaires to assess psychological morbidity (grief, post\u2010traumatic stress and postnatal depression and quality of life [QoL]), and factors that could potentially influence outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 241 participants, women displayed more pronounced psychological distress than men, though both groups improved over time. Four months after termination, 27.4% of women and 9.1% of men showed signs of pathological grief. Scores indicative for postnatal depression occurred in 19.8% women and 4.1% of men. A prior psychiatric history was a consistent predictor of poorer outcomes. Fetal donation to the Dutch Fetal Biobank was associated with reduced likelihood of symptoms of complicated grief four months after termination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Second\u2010trimester termination of pregnancy for fetal anomalies can lead to psychological morbidity, particularly in women. However, there is a notable improvement over time for both groups. Individuals with prior psychiatric history appear more vulnerable post\u2010termination. Also, fetal donation to science did not have a negative impact on psychological well\u2010being.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14848","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T05:55:42Z","timestamp":1720504542000},"page":"1868-1876","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Psychological sequelae following second\u2010trimester termination of pregnancy: A longitudinal study"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1218-3540","authenticated-orcid":false,"given":"Yousif","family":"Dawood","sequence":"first","affiliation":[{"name":"Department of Medical Biology Amsterdam UMC, University of Amsterdam  Amsterdam the Netherlands"},{"name":"Department of Obstetrics and Gynecology Amsterdam UMC, University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Reproduction and Development Research Institute  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana M.","family":"de Vries","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Amsterdam UMC, University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Reproduction and Development Research Institute  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Amsterdam UMC, University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Reproduction and Development Research Institute  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rik","family":"van Eekelen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Data Science Amsterdam UMC, Location VUmc  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette S.","family":"de Bakker","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Amsterdam UMC, University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Reproduction and Development Research Institute  Amsterdam the Netherlands"},{"name":"Department of Pediatric Surgery Erasmus MC \u2013 Sophia Children's Hospital, University Medical Center Rotterdam  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Boelen","sequence":"additional","affiliation":[{"name":"ARQ National Psychotrauma Center  Diemen the Netherlands"},{"name":"Department of Clinical Psychology Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Pajkrt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Amsterdam UMC, University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Reproduction and Development Research Institute  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.midw.2021.103095"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443610400022967"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1127"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970120308"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1763"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.04.007"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.636"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1307"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1854"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2023.11.019"},{"key":"e_1_2_11_12_1","volume-title":"Measurement of perceived self\u2010efficacy. 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