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Reduced risk of hypertensive disorders, hypoglycemia, and macrosomia are potential benefits, together with lower gestational weight gain. Although metformin has been prescribed for pregnant women during the last 40\u2009years, long\u2010term data regarding offspring outcomes are still lacking. Independent of maternal glycemic control, recent meta\u2010analyses report lower birthweight but accelerated postnatal growth and higher body mass index in metformin\u2010exposed children. The longest follow\u2010up study of placebo\u2010controlled metformin exposure in utero found an increased prevalence of central adiposity and obesity among children 5\u201310\u2009years old. Recently, a Danish study reported a threefold increased risk of genital anomalies in boys, whose fathers used metformin around the time of conception. This commentary addresses the current controversies on metformin use in pregnancy.<\/jats:p>","DOI":"10.1111\/aogs.14878","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T04:24:13Z","timestamp":1715919853000},"page":"1238-1241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Metformin use in pregnancy: What about long\u2010term effects in offspring?"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4583-2743","authenticated-orcid":false,"given":"Johanne Holm","family":"Toft","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Stavanger University Hospital  Stavanger Norway"},{"name":"Department of Clinical Science University of Bergen  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0150-4919","authenticated-orcid":false,"given":"Inger","family":"\u00d8kland","sequence":"additional","affiliation":[{"name":"Department of Caring and Ethics University of Stavanger  Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4351-y"},{"key":"e_1_2_11_3_1","unstructured":"Merck.PRESS RELEASES: Glucophage\u00ae is the first oral diabetes treatment approved in Europe for use during pregnancy.2022.https:\/\/www.merckgroup.com\/en\/news\/glucophage\u2010oral\u2010diabetes\u2010treatment\u201028\u201002\u20102022.html"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-S015"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002159"},{"key":"e_1_2_11_6_1","volume-title":"Global Guideline on Pregnancy and Diabetes Brussels","author":"International Diabetes Federation","year":"2009"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.01.041"},{"key":"e_1_2_11_8_1","volume-title":"Diabetes in Pregnancy: Management of Diabetes and Its Complications from Preconception to the Postnatal Period","author":"National Institute for Health and Care Excellence","year":"2015"},{"key":"e_1_2_11_9_1","unstructured":"Norwegian Directorate of Health.Nasjonal faglig retningslinje for svangerskapsdiabetes.2017.https:\/\/www.helsedirektoratet.no\/retningslinjer\/svangerskapsdiabetes"},{"key":"e_1_2_11_10_1","unstructured":"Dansk Endokrinologisk Selskab.Pr\u00e6eksisterende diabetes og graviditet.2024. 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