{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T04:01:55Z","timestamp":1743998515862,"version":"3.40.3"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>There is a major research gap relating to the impact of intravenous (IV) fluids administration during labor on maternal and neonatal outcomes. It is biologically plausible that a relationship between volume of IV fluids and primary postpartum hemorrhage (PPH) exists. The primary objective of this study was to evaluate whether the administration of high\u2010volume IV fluids during labor (\u2265\u20092500\u2009mL) increases the risk of primary PPH and other adverse outcomes for women with a term, singleton pregnancy, in comparison to low\u2010volume IV fluids during labor (&lt;2500\u2009mL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A retrospective cohort study was conducted at a tertiary referral hospital in Sydney, Australia between 1st September 2021 and 31st October 2022. Inclusion criteria were: women with a live singleton fetus in a cephalic presentation; planning a vaginal birth; and admitted for labor and birth care between 37 and 42\u2009week gestation. The study factor was IV fluids during labor and the primary outcome was primary PPH \u2265500\u2009mL. Secondary outcomes included cesarean section and major perineal injury. Pregnancy, birth, and postnatal data were obtained from the hospital's electronic clinical database, electronic medical records, and paper fluid order documentation. Multivariable logistic regression and multiple imputation were used to explore the relationship between volume of IV fluids in labor and PPH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1023 participants were included of which 339 had a primary PPH (33.1%). There was no association between high\u2010volume IV fluids and PPH after adjusting for demographic and clinical factors (adjusted odds ratio [OR<jats:sub>adj<\/jats:sub>]1.02 95% confidence interval [95%CI] 0.72, 1.44). However, there was a positive association between high\u2010volume IV fluids and cesarean section (OR<jats:sub>adj<\/jats:sub> 1.99; 95%CI 1.4, 2.8).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings of this research are important to further knowledge relating to the administration of IV fluids during labor. The findings emphasize the importance of accurately documenting IV fluids administration and identifies research priorities to enable us to better understand the broader implications of IV fluids administration on pregnancy and perinatal outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14896","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T13:04:02Z","timestamp":1718024642000},"page":"1541-1549","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between intravenous fluids during labor and primary postpartum hemorrhage: A retrospective cohort study"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0772-6093","authenticated-orcid":false,"given":"Belinda R.","family":"Bruce","sequence":"first","affiliation":[{"name":"Susan Wakil School of Nursing and Midwifery, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"},{"name":"Sydney Institute for Women, Children and their Families RPA Women and Babies, Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather L.","family":"Shepherd","sequence":"additional","affiliation":[{"name":"Susan Wakil School of Nursing and Midwifery, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saleem Ahmed","family":"Khan","sequence":"additional","affiliation":[{"name":"RPA Women and Babies, Royal Prince Alfred Hospital  Sydney New\u00a0South\u00a0Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte R.","family":"Haunton","sequence":"additional","affiliation":[{"name":"RPA Women and Babies, Royal Prince Alfred Hospital  Sydney New\u00a0South\u00a0Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Leask","sequence":"additional","affiliation":[{"name":"Susan Wakil School of Nursing and Midwifery, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"},{"name":"School of Public Health, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5620-0170","authenticated-orcid":false,"given":"Bradley S.","family":"De\u00a0Vries","sequence":"additional","affiliation":[{"name":"Sydney Institute for Women, Children and their Families RPA Women and Babies, Royal Prince Alfred Hospital  Sydney New South Wales Australia"},{"name":"Central Clinical School, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2022.11.001"},{"issue":"2","key":"e_1_2_12_3_1","article-title":"Treatment for primary postpartum haemorrhage","volume":"2014","author":"Mousa HA","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-9-55"},{"key":"e_1_2_12_5_1","unstructured":"World Health Organization.WHO recommendations for the prevention and treatment of postpartum haemorrhage.2012. 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