{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:47:19Z","timestamp":1770752839707,"version":"3.50.0"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Previous studies have indicated the association between smooth endoplasmic reticulum aggregates (SERa+) and poorer medically assisted reproduction outcomes. However, the link between SERa+ and neonatal outcomes remains controversial and open for debate. A comprehensive meta\u2010analysis on the relation between SERa+ and the risk of birth defects is needed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>The literature search was conducted using the following databases: PubMed, Embase, Cochrane Libraries, Web of Science, and Chinese databases including China National Knowledge Infrastructure (CNKI) and Wan Fang from inception until July 2023. Risk ratio (RR) and 95% confidence interval (CI) were calculated by a fixed\u2010effected model, while heterogeneity was assessed by forest plots and <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> statistic. Funnel plot was produced to assess publication bias. This meta\u2010analysis has been registered on PROSPERO (CRD42022313387).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The search resulted in 122 studies, 14 of which met the inclusion criteria. The analysis of birth defects revealed a higher risk (RR\u2009=\u20092.17, 95%CI 1.24 to 3.81, <jats:italic>p<\/jats:italic>\u2009=\u20090.007) in children derived from SERa+ cycle compared to SERa\u2010 cycles (711 vs. 4633). Meanwhile, in a subgroup analysis, the risk of birth defects was significantly increased in the SERa+ oocytes group as compared with the sibling SERa\u2010 oocytes group (RR\u2009=\u20093.53, 95%CI 1.21 to 10.24, <jats:italic>p<\/jats:italic>\u2009=\u20090.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To conclude, our analysis indicated that SERa+ cycles\/oocytes may have a potential risk of increased additional major birth defects comparing with SERa\u2010 cycles\/oocytes. This conclusion may provide evidence\u2010based support for clinicians in IVF clinical guidance and embryologists in prudent embryo selection strategy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14910","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T01:16:17Z","timestamp":1720055777000},"page":"2163-2170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Smooth endoplasmic reticulum aggregates in oocytes associated with increased risk of neonatal birth defects: A\u00a0meta\u2010analysis"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5047-2589","authenticated-orcid":false,"given":"Rui","family":"Long","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan 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