{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T10:25:07Z","timestamp":1774607107360,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The aim of this study was to investigate the presence of aortic isthmus flow reversal and its associated factors in fetuses with positive and false\u2010positive coarctation of the aorta (CoA) compared with normal controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Pregnant women with fetuses suspected of CoA and normal control were enrolled, and these women experienced prenatal ultrasound scan and followed up for 6\u2009months after birth to confirm the presence of CoA. All the ultrasound parameters were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 134 pregnant women were enrolled, with 43 CoA\u2010positive fetuses and 91 CoA false\u2010positive fetuses, and 334 matched pregnant women were enrolled in the control group. Aortic isthmus flow reversal occurred in 28 (65.1%) fetuses in the CoA\u2010positive group, significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) more than in the false\u2010positive (37 or 40.7%) or control group (64 or 19.2%). Aortic isthmus flow reversal was mostly in the full systole (<jats:italic>n<\/jats:italic>\u2009=\u200917 or 60.7%) or late systole and early\u2010middle diastole (<jats:italic>n<\/jats:italic>\u2009=\u200910 or 35.7%) in the CoA\u2010positive fetuses (<jats:italic>n<\/jats:italic>\u2009=\u200927 or 96.4%), significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) different from that in the false\u2010positive or control group. The aortic isthmus flow reversal peak systolic velocity (PSV), flow volume, and ratio of reversed flow\/forward flow were significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) increased in the CoA\u2010positive and false\u2010positive groups than in the control group. The aortic isthmus flow reversal incidence was significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) correlated with the middle cerebral artery (MCA) PSV in the total three groups or in the false\u2010positive group but was significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090001) negatively correlated with the MCA resistance index (RI) in the CoA\u2010positive group. The incidence of the aortic isthmus flow reversal was significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) positively correlated with the umbilical artery (UA) RI in the false\u2010positive group and with the UA RI in the total three groups. Independently associated factors for aortic isthmus flow reversal were isthmic flow volume\/CCO (combined cardiac output) in the CoA\u2010positive group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Reversal of flow in the aortic isthmus is much more common in true\u2010positive cases of CoA as compared to controls, and isthmic flow reversal in the full systolic phase only suggests presence of CoA. The aortic isthmic reversed flow volume accounts for over half of the isthmic forward flow volume in the CoA\u2010positive fetuses than in the normal controls.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14940","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T12:15:45Z","timestamp":1726575345000},"page":"2264-2272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Aortic isthmus flow reversal in fetal coarctation of the aorta and the associated factors"],"prefix":"10.1111","volume":"103","author":[{"given":"Guihong","family":"Chen","sequence":"first","affiliation":[{"name":"Research Center for Clinical Medical Sciences The Fourth Hospital of Shijiazhuang  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongfeng","family":"Han","sequence":"additional","affiliation":[{"name":"Research Center for Clinical Medical Sciences The Fourth Hospital of Shijiazhuang  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congxin","family":"Sun","sequence":"additional","affiliation":[{"name":"Research Center for Clinical Medical Sciences The Fourth Hospital of Shijiazhuang  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xiang","sequence":"additional","affiliation":[{"name":"Research Center for Clinical Medical Sciences The Fourth Hospital of Shijiazhuang  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Research Center for Clinical Medical Sciences The Fourth Hospital of Shijiazhuang  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Research Center for Clinical Medical Sciences The Fourth Hospital of Shijiazhuang  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianxiao","family":"Yu","sequence":"additional","affiliation":[{"name":"Research Center for Clinical Medical Sciences The Fourth Hospital of Shijiazhuang  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuo","family":"Chen","sequence":"additional","affiliation":[{"name":"Echocardiography Medical Center, Maternal\u2010Fetal Medicine center in Fetal Heart Disease, Beijing Anzhen Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4668-0737","authenticated-orcid":false,"given":"Bulang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shijiazhuang People's Hospital  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuping","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adult Congenital Cardiology, Geisinger Heart and Vascular Institute Geisinger Medical Center  Danville Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Mi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shijiazhuang People's Hospital  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12070"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12892"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.08.008"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.911"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00446-7"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.6.1531"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.3.741"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.787598"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semperi.2022.151584"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000530020"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims-21-644"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.27576"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12165190"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2710"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4753"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.71.1.70"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2023.04.014"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(94)90908-3"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13345"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00801914"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6406"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70157-7"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.17772\/gp\/1762"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1993.tb12600.x"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.110696"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.08.026"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5237"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70089-X"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.232"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.2015.58.1.17"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.14940","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T05:02:18Z","timestamp":1755666138000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.14940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,16]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/aogs.14940"],"URL":"https:\/\/doi.org\/10.1111\/aogs.14940","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,16]]},"assertion":[{"value":"2024-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}