{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:05:20Z","timestamp":1793059520951,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010198","name":"Ministerio de Asuntos Econ\u00f3micos y Transformaci\u00f3n Digital, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>This study aims to evaluate the safety of discontinuing aspirin treatment at 24\u201328\u2009weeks in women at high risk after first\u2010trimester combined screening for preeclampsia (PE) and normal placental growth factor (PlGF) levels at 24\u201328\u2009weeks of gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>This is a post hoc analysis of the StopPRE trial, conducted at nine Spanish maternity hospitals from September 2019 to September 2021. In the StopPRE trial, all high\u2010risk single pregnancies identified during first\u2010trimester screening for PE were treated with 150\u2009mg of daily aspirin. Out of 1604 eligible women with a soluble fms\u2010like tyrosine kinase\u20101 to PlGF ratio (sFlt\u20101\/PlGF) \u226438 at 24\u201328\u2009weeks, 968 were randomly assigned in a 1:1 ratio to either continue aspirin until 36\u2009weeks (control group) or discontinue it (intervention group). In this secondary analysis, only women with PlGF \u2265100\u2009pg\/mL at 24\u201328\u2009weeks were included. As in the StopPRE trial, the non\u2010inferiority margin was set at a 1.9% difference in preterm PE incidence between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 13\u2009983 screened pregnant women, 1984 (14.2%) were deemed high\u2010risk for preterm PE, of which 397 (20.0%) were ineligible, 636 declined participation, and 32 were excluded. Ultimately, 919 women with PlGF &gt;100\u2009pg\/mL were randomized and included in this analysis. Preterm PE occurred in 0.9% of the intervention group (4 out of 465) and 1.5% of the control group (7 out of 454), indicating non\u2010inferiority of aspirin discontinuation. There were no significant differences between the groups in adverse pregnancy outcomes before 37\u2009weeks, at &lt;34\u2009weeks, or \u226537\u2009weeks. Minor antepartum hemorrhage incidence was significantly lower in the intervention group (absolute difference, \u22125.96; 95% CI, \u221210.10 to \u22121.82).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Discontinuation of aspirin treatment at 24\u201328\u2009weeks in women with PlGF levels \u2265100\u2009pg\/mL was non\u2010inferior to continuing until 36\u2009weeks for preventing preterm PE. However, these findings should be interpreted with caution, as they originate from a subanalysis of the StopPRE trial.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14955","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T15:33:19Z","timestamp":1724340799000},"page":"2273-2280","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Placental growth factor at 24\u201328\u2009weeks for aspirin discontinuation in pregnancies at high risk for preterm preeclampsia: Post hoc analysis of <scp>StopPRE<\/scp> trial"],"prefix":"10.1111","volume":"103","author":[{"given":"Marta","family":"Ricart","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Obstetrics and Gynecology, and Preventive Medicine and Public Health Universitat Aut\u00f2noma de Barcelona  Bellaterra Spain"},{"name":"Department of Obstetrics Hospital Universitari Germans Trias i Pujol  Badalona 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