{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:39:57Z","timestamp":1789184397672,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007403","name":"Dagmar Marshalls Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007403","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010346","name":"Else og Mogens Wedell Wedellsborgs Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010346","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010347","name":"Fabrikant Einar Willumsens Mindelegat","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020035","name":"A. P. M\u00f8llerske St\u00f8ttefond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Diagnostic work\u2010up of older women with a positive cervical cancer screening test is often challenging due to incomplete visualization of the transformation zone. To reduce the risk of missing disease, a diagnostic cervical excision may be performed. However, little is known on treatment efficacy and post\u2010treatment surveillance for older women. We aimed to investigate the proportion of women testing negative for human papillomavirus (HPV) following a diagnostic cervical excision due to an abnormal screening test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>We conducted a prospective cohort study on women aged \u226545\u2009years who were referred for colposcopy due to an abnormal screening test between March 2019 and June 2021. All women had incomplete visualization of the transformation zone and underwent colposcopy and a diagnostic cervical excision at the first visit. Women were followed from date of excision until January 30, 2023. Follow\u2010up data was retrieved from the Danish Pathology Databank, and baseline characteristics were obtained from medical records. Cox regression was used on interval\u2010censored data to estimate crude and adjusted hazard ratios for a negative HPV test after cervical excision, stratified by histology and age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 100 women underwent a diagnostic cervical excision and had at least one HPV test during follow\u2010up. Median age was 67.4\u2009years, and median follow\u2010up time was 2.9\u2009years. At the end of follow\u2010up, 70% tested HPV negative. Women with cervical intraepithelial neoplasia grade two or worse in their excision specimen were more likely to test HPV negative at the first test after cervical excision compared to women with less than cervical intraepithelial neoplasia grade two, however, not statistically significant (adjusted hazard ratio 1.69, 95% CI 0.92\u20133.10). Women aged 65\u201384\u2009years were less likely to test HPV negative compared to women &lt;65\u2009years (adjusted hazard ratio 0.49, 95% CI 0.28\u20130.87).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In older women undergoing a diagnostic cervical excision, 70% tested HPV negative after 2.9\u2009years, leaving 30% with persistent HPV positivity. More studies are needed to determine the risks associated with continued HPV positivity in the absence of high\u2010grade disease. Furthermore, given the absence of specific guidelines, the optimal surveillance frequency remains unknown.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.15019","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T12:38:29Z","timestamp":1735821509000},"page":"342-349","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["High rate of persistent HPV detection after diagnostic cervical excision in older screen\u2010positive women"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4149-4708","authenticated-orcid":false,"given":"Line Winther","family":"Gustafson","sequence":"first","affiliation":[{"name":"University Research Clinic for Cancer Screening Department of Public Health Programmes, Randers Regional Hospital  Randers Denmark"},{"name":"Department of Obstetrics and Gynecology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7237-4536","authenticated-orcid":false,"given":"Louise","family":"Krog","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bayan","family":"Sardini","sequence":"additional","affiliation":[{"name":"University Research Clinic for Cancer Screening Department of Public Health Programmes, Randers Regional Hospital  Randers Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette","family":"Tranberg","sequence":"additional","affiliation":[{"name":"University Research Clinic for Cancer Screening Department of Public Health Programmes, Randers Regional Hospital  Randers Denmark"},{"name":"Department of Pathology Randers Regional Hospital  Randers Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone Kjeld","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Medicine University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berit","family":"Andersen","sequence":"additional","affiliation":[{"name":"University Research Clinic for Cancer Screening Department of Public Health Programmes, Randers Regional Hospital  Randers Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinar","family":"Bor","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Obstetrics and Gynecology Randers Regional Hospital  Randers Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4616-9827","authenticated-orcid":false,"given":"Anne","family":"Hammer","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"University Clinic for HPV\u2010related Gynecological Disease Department of Obstetrics and Gynecology, G\u00f8dstrup Hospital  Herning Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.14162"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17200"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-017-1124-z"},{"key":"e_1_2_12_5_1","first-page":"1465","article-title":"Surgery for cervical intraepithelial neoplasia","volume":"12","author":"Martin\u2010Hirsch PP","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_12_6_1","unstructured":"PetersenL SchrollJ DollerisBB et\u00a0al.National clinical guideline for cervical dysplasia. 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