{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:08:07Z","timestamp":1791932887725,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008403","name":"Suomalainen L\u00e4\u00e4k\u00e4riseura Duodecim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008403","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>To evaluate predicting clinical factors for regression and progression of cervical intraepithelial neoplasia (CIN) grade 2 (CIN2) in young women during two years of active surveillance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>This was a single\u2010center prospective observational cohort study. Women under 31\u2009years of age giving written informed consent with histologically confirmed CIN2 were followed with colposcopy, cytology, and biopsies every 6\u2009months up to 24\u2009months. At baseline, HPV genotyping was performed on cervical samples. The rates of regression and progression were recorded for every timepoint and at the end of study overall and stratified according to clinical factors and HPV genotypes at baseline. Risk ratio (RR) was used to estimate the relative risks for regression and progression. The study was registered in the ISRCTN registry (ISRCTN91953024).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 205\/243 (84.4%) women completed the study. Complete regression (normal histology and\/or normal or atypical squamous cells of undetermined significance (ASC\u2010US) cytology) was detected in 64.4.% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009132) while 16.1% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200933) of the lesions progressed to CIN grade 3 (CIN3) or worse including 31 CIN3 cases, one adenocarcinoma in\u00a0situ and one cervical cancer case. Factors associated with progression were initial large (&gt;50% of the transformation zone) lesion size, risk ratio (RR) 3.06 (95% confidence interval (CI) 1.40\u20136.69), and high\u2010grade referral cytology RR 4.73 (95% CI 1.18\u201319.03). Compared with baseline HPV negativity or having only low\u2010risk HPV genotypes present, high\u2010risk HPV (hrHPV) positivity was associated with lower likelihood of regression RR 0.74 (95% CI 0.60\u20130.91). Age, cigarette smoking, use of combined oral contraceptives or baseline high\u2010risk HPV genotype, including HPV16, were not associated with the outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The majority of CIN2 lesions regress in young women. Women with large lesions and\/or high\u2010grade referral cytology should perhaps more often be treated instead of active surveillance. Initial hrHPV genotype does not appear to predict outcomes while not harboring hrHPV favors regression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.15032","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:52:12Z","timestamp":1739235132000},"page":"763-773","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Predictors for regression and progression of actively surveilled cervical intraepithelial neoplasia grade 2: A prospective cohort study"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2047-9392","authenticated-orcid":false,"given":"Laura","family":"Bergqvist","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7467-8434","authenticated-orcid":false,"given":"Anni","family":"Virtanen","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Helsinki and HUS Diagnostic Center, Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilkka","family":"Kalliala","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Helsinki and Helsinki University Hospital  Helsinki Finland"},{"name":"Department of Metabolism, Digestion and Reproduction, Faculty of Medicine Institute of Reproductive and Developmental Biology, Imperial College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"B\u00fctzow","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Helsinki and HUS Diagnostic Center, Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maija","family":"Jakobsson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hyvink\u00e4\u00e4 Hospital, Helsinki University Hospital and University of Helsinki  Hyvink\u00e4\u00e4 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annu","family":"Heinonen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1172-363X","authenticated-orcid":false,"given":"Karolina","family":"Louvanto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tampere University Hospital  Tampere Finland"},{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine and Health Technology Tampere University  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joakim","family":"Dillner","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Karolinska Institute  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pekka","family":"Nieminen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3467-7194","authenticated-orcid":false,"given":"Karoliina","family":"Aro","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000525"},{"key":"e_1_2_13_3_1","unstructured":"Working group set up by the Finnish Medical Society Duodecim and the Finnish Colposcopy Association.Cytological Changes in the Cervix Vagina and Vulva. 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