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To help the evidence\u2010based decision\u2010making of women when choosing contraception methods, we aimed to provide them with an up\u2010to\u2010date overview and summary of past and recent findings on the association between the use of oral contraceptives and endometrial cancer risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>This study was registered in PROSPERO: CRD42022379871. PubMed, Embase, and Cochrane Library databases were searched on the December 5, 2022, to identify eligible articles. We included all experimental and observational studies that reported the number of users and non\u2010users of oral contraceptives among patients diagnosed or not with endometrial cancer. Data were extracted, and random\u2010effects meta\u2010analysis was performed to obtain summary odds ratios (OR) with 95% confidence intervals (CI). Heterogeneity across studies was assessed using Higgins &amp; Thompson's <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> statistic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010six studies were eligible for qualitative synthesis, of which twenty\u2010five were eligible for quantitative analysis. The use of oral contraceptives was inversely associated with the odds of having endometrial cancer (OR\u2009=\u20090.61, CI: 0.46\u20130.80). The long\u2010term use of oral contraceptives led to the greatest odds reduction in having endometrial cancer (\u226510\u2009years: OR\u2009=\u20090.31, CI: 0.13\u20130.70), while shorter periods were also associated with a significant decrease in these odds, although to a lesser extent (\u22655\u2009years: OR\u2009=\u20090.39, CI: 0.23\u20130.64; &lt;5\u2009years: OR\u2009=\u20090.66, CI: 0.48\u20130.91).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The administration of oral contraceptives is time dependently associated with lower odds of having endometrial cancer, suggesting a protective association between the use of oral contraceptives and endometrial 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