{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:45:11Z","timestamp":1787751911165,"version":"build-2784847793"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>To report the progress of the human living uterus transplant research project in Singapore.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>The uterus transplant research project began in 2012 with a collaboration between the Swedish and Singapore teams. Ethics approval was obtained from the SingHealth Centralised Institutional Review Board, the SingHealth Transplant and the Singapore General Hospital Biomedical Ethics Committee to perform 5 uterus transplant procedures in a collaborative multi\u2010site research study at the Singapore General Hospital. Regulatory approval was obtained from the Ministry of Health, Singapore. A suitable recipient\u2013donor pair was identified. The living donor was the perimenopausal mother\u2010in\u2010law of the recipient who had Mayer\u2013Rokitansky\u2013Kuster\u2013Hauser syndrome. They underwent the requisite matching process as well as robust medical, psychiatric and psychosocial assessments. The recipient then underwent in\u00a0vitro fertilization (IVF) treatment resulting in 6 frozen blastocysts. Preparations were made for the transplant surgery on 25 November 2023 in Singapore General Hospital, aided by the 3 Uterus transplant experts from the Swedish Team, for whom temporary registration was granted by the Singapore Medical Council.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This first uterus transplant procedure involved an operative time of 10\u2009h and 30\u2009min for the donor. The synchronized recipient surgery lasted 6\u2009h and 20\u2009min. Surgery was by midline laparotomy in both the living donor and recipient. The total warm ischemic time of the graft was 45\u2009min, and the cold ischemic time was 1\u2009h 45\u2009min (total ischemic time 2\u2009h 30\u2009min). The patient's first menstruation occurred 38\u2009days after the uterus transplant procedure. Cytomegalovirus infection was detected 6\u2009weeks postoperatively for which she was aggressively treated. Serial cervical biopsies showed no rejection and Doppler ultrasound of the transplanted uterus showed good uterine blood flow.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To date the Living Donor Uterus Transplant Research Project in Singapore has progressed with a uterus transplant surgery involving a living donor performed by a multidisciplinary team. The recipient had a menstrual period 38\u2009days postoperatively. Further study of the outcomes from this procedure will inform the safety and efficacy of uterus transplant in the Singapore context.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.15048","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T10:25:39Z","timestamp":1738059939000},"page":"548-558","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Living donor uterus transplant research project in Singapore: Progress of the first case"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2089-5620","authenticated-orcid":false,"given":"Hak Koon","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Singapore General Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence Y. 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