{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T23:10:50Z","timestamp":1776553850528,"version":"3.51.2"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["22Y21900800"],"award-info":[{"award-number":["22Y21900800"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201886"],"award-info":[{"award-number":["82201886"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271732"],"award-info":[{"award-number":["82271732"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Ectopic pregnancy (EP) is a serious clinical gynecological emergency. Patients with EP history are at higher risk of EP resulting from IVF\/ICSI (IVF\u2010EP). Besides, studies have suggested that previous EP treatments may affect the incidence of IVF\u2010EP. However, this result does not consider possible confounding factors due to the number of previous EP. Therefore, we assessed the impact of salpingectomy on the risk and characteristics of IVF\u2010EP in patients with different previous spontaneous EP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>This retrospective cohort study included 43\u2009647 patients receiving their first IVF\/ICSI treatments at our center from January 2013 to June 2022. Cohorts were assigned according to the number of previous spontaneous EP by propensity score matching. After propensity score matching, there were 3252 participants in the no previous EP history cohort (NEP cohort), 3252 in the one EP history cohort (One\u2010EP cohort), and 1571 in the 2 or more EP history cohort (&gt;\u2009=\u20092 EP cohort). To assess the effect of previous salpingectomy on IVF\u2010EP, One\u2010EP cohort and\u2009&gt;\u2009=2 EP cohort were divided into three subcohorts separately, according to their tubal statuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The IVF\u2010EP rate was significantly higher in patients with EP history (NEP cohort: 1.3% vs. One\u2010EP cohort: 2.2% vs.\u2009&gt;=2 EP cohort: 2.0%, <jats:italic>p<\/jats:italic>\u2009=\u20090.023). In subcohort analysis, patients with different tubal statuses presented no statistical differences in IVF\u2010EP rate (both in One\u2010EP cohort and\u2009&gt;\u2009=2 EP cohort). Considering the interaction between tubal status and number of previous EP, binary logistic regression was performed and it was demonstrated that bilateral salpingectomy might reduce the risk of IVF\u2010EP in patients with recurrent EP history but increase the risk of non\u2010tubal IVF\u2010EP, while the history of spontaneous EP increased both IVF\u2010EP and non\u2010tubal IVF\u2010EP rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Previous EP history was associated with a higher risk of IVF\u2010EP and non\u2010tubal IVF\u2010EP. Salpingectomy reduced the overall risk of IVF\u2010EP in patients with EP history, while bilateral salpingectomy increased the risk of non\u2010tubal IVF\u2010EP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.15059","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T13:51:34Z","timestamp":1737985894000},"page":"720-728","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of salpingectomy on the risk and characteristics of ectopic pregnancy after IVF\/ICSI in patients with ectopic pregnancy history: A large retrospective cohort study"],"prefix":"10.1111","volume":"104","author":[{"given":"Xueyi","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Assisted Reproduction, Shanghai Ninth People's Hospital Shanghai JiaoTong University School of Medicine  Shanghai 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