{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T10:41:16Z","timestamp":1793529676100,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Uterine fibroids are the most common benign tumors among women, and it is estimated that approximately 70% of women have one or multiple fibroids by the age of menopause. About 30% of these women suffer from symptoms related to the fibroids. Magnetic resonance\u2010guided high\u2010intensity focused ultrasound (MR\u2010HIFU) is a novel, non\u2010invasive treatment method for symptomatic uterine fibroids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>In this prospective, single\u2010centre follow\u2010up study, 175 women with symptomatic uterine fibroids were treated with MR\u2010HIFU. The effect of MR\u2010HIFU on fibroid symptoms and quality of life was evaluated using a uterine fibroid\u2010specific quality of life questionnaire (UFS\u2010QoL). The main outcome measure was the symptom severity score and quality of life (QoL) before the MR\u2010HIFU and 3 and 12\u2009months after the treatment. This study was registered at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link> (NCT03937401).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median symptom severity score decreased from 56 (IQR 44\u201369) at baseline to 28 (IQR 16\u201344) at 3\u2009months (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and 25 (IQR 16\u201338) at 12\u2009months (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) after treatment. The QoL score increased from a median of 48 (IQR 33\u201366) at baseline to 73 (IQR 59\u201393) at 3\u2009months (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and 78 (IQR 66\u201390) at 12\u2009months after treatment (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The reintervention rate during the 12\u2010month follow\u2010up was 2%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MR\u2010HIFU significantly reduces the severity of fibroid\u2010related symptoms in selected patients as early as 3\u2009months after MR\u2010HIFU. The effect persists at 12\u2009months. There is also a significant improvement in the quality of life 3\u2009months after treatment, which further increases at 12\u2009months.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.15086","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T05:40:43Z","timestamp":1745991643000},"page":"1172-1180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Magnetic resonance guided high intensity focused ultrasound (<scp>MR<\/scp>\u2010<scp>HIFU<\/scp>) effectively reduces fibroid\u2010related symptoms and improves quality of life\u2014A prospective single\u2010centre 12\u2010month follow\u2010up study"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7873-1204","authenticated-orcid":false,"given":"Saara","family":"Otonkoski","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Turku University Hospital  Turku 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