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This study aimed to assess maternal antibodies to <jats:italic>C. trachomatis<\/jats:italic> and <jats:italic>M. genitalium<\/jats:italic> in newborns, their vanishing, and offspring's own seroconversion to these pathogens during the first 3\u2009years of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Altogether, 309 mother\u2010neonate pairs originally enrolled in the prospective Finnish Family HPV (FFHPV) cohort study at Turku University Hospital, Finland, were analyzed for serum IgG antibodies to plasmid protein gene 3 (pGP3) for <jats:italic>C. trachomatis<\/jats:italic> and <jats:italic>M. genitalium<\/jats:italic> protein of adhesion (MgPa N\u2010term) and recombinant MgPa for <jats:italic>M. genitalium<\/jats:italic> using multiplex serology, by serial sampling during a 3\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant correlation between maternal and neonate antibodies to both <jats:italic>C. trachomatis<\/jats:italic> and <jats:italic>M<\/jats:italic>. <jats:italic>genitalium<\/jats:italic> was evident up to 2\u2009months after birth and to <jats:italic>C. trachomatis<\/jats:italic> also at 6\u2009months (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). During the first 3\u2009years of life, three children seroconverted IgG antibodies to <jats:italic>C. trachomatis<\/jats:italic> and one to <jats:italic>M. genitalium<\/jats:italic>. At the last (36\u2010month) follow\u2010up visit, five (2.1%) children were seropositive for <jats:italic>C. trachomatis<\/jats:italic> and only one (0.4%) for <jats:italic>M. genitalium<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both <jats:italic>C. trachomatis<\/jats:italic> and <jats:italic>M. genitalium<\/jats:italic> IgG antibodies are transferred from the mother to her offspring during pregnancy; similarly, this is shown for nearly all maternal IgG antibodies. Seroconversion for both <jats:italic>C. trachomatis<\/jats:italic> and <jats:italic>M. genitalium<\/jats:italic> in early childhood was a rare event. Further studies are required to elucidate the significance of <jats:italic>C. trachomatis<\/jats:italic> and <jats:italic>M. genitalium<\/jats:italic> antibodies acquired in early life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.15105","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T13:29:39Z","timestamp":1748352579000},"page":"1366-1372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal\u2013fetal transfer and longitudinal trends of antibodies to <i>Chlamydia trachomatis<\/i> and <i>Mycoplasma genitalium<\/i> in early childhood"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0337-7420","authenticated-orcid":false,"given":"Nea","family":"Koskela","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine and Health Technology Tampere University  Tampere 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