{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:24:26Z","timestamp":1767007466331,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C8162\/A27047"],"award-info":[{"award-number":["C8162\/A27047"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>For women treated for cervical dysplasia at 60\u201364\u2009years in Denmark, we reported the frequency of abnormalities before and after treatment of cervix uteri (most frequently performed as large loop excision of the cervical transformation zone, LLETZ) using population\u2010based real\u2010world data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>We conducted a retrospective cohort study based on national data from the Danish Pathology Data Bank and identified women who underwent a LLETZ in 2010\u20132016 at the age of 60\u201364. Women were managed according to nationwide evidence\u2010based recommendations proposed by the Danish professional organizations. We retrieved information on all LLETZ specimens, cervical histology, cytology, and human papillomavirus (HPV) tests in the period of 2\u2009years prior to the procedure to 2\u2009years thereafter. We reported the frequencies of abnormalities before, at, or after the procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1014 women who had a LLETZ during the study period, 660 (65%) showed cervical intraepithelial neoplasia grade 1 or worse (CIN1+, including CIN1, CIN2, CIN3, cervical cancer, and CIN not otherwise specified) in their LLETZ specimen, with free resection margins in 255 (39%). Of the 1014 women, 551 (54%) had CIN2+ in a biopsy preceding the LLETZ and in 567 (56%) CIN2+ was found in their LLETZ specimen. In 37 (4%) women, the specimen showed cervical cancer; whereas in the pre\u2010LLETZ biopsies of these 37 women, cancer was detected in only 7 (1%). After LLETZ, 818 (81%) women underwent test\u2010of\u2010cure follow\u2010up which was positive in 406 women (40%). Furthermore, 408 (40%) women had new histological samples registered after LLETZ. These showed CIN2+ in 134 (13%) women, whereas a new cancer was diagnosed in 11 (1%) women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Due to persistent abnormal tests after LLETZ, an extended follow\u2010up is still required for a large proportion of the women in this age group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.15111","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T22:01:49Z","timestamp":1744063309000},"page":"1112-1119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Outcomes associated with large loop excision of the cervical transformation zone in women 60\u201364\u2009years of age: A population\u2010based register study from Denmark"],"prefix":"10.1111","volume":"104","author":[{"given":"Julie Laub","family":"Erdal","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza Rafiolsadat","family":"Serizawa","sequence":"additional","affiliation":[{"name":"Department of Pathology Copenhagen University Hospital Amager and Hvidovre  Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9597-645X","authenticated-orcid":false,"given":"Matejka","family":"Rebolj","sequence":"additional","affiliation":[{"name":"Centre for Cancer Screening, Prevention and Early Diagnosis, Wolfson Institute of Population Health Queen Mary University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1776-0562","authenticated-orcid":false,"given":"Jeppe Bennekou","family":"Schroll","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Centre for Evidence\u2010Based Medicine Odense and Cochrane Denmark University of Southern Denmark  Odense Denmark"},{"name":"Open Patient Data Explorative Network Odense University Hospital  Odense Denmark"},{"name":"Department of Gynecology &amp; Obstetrics Herlev\u2010Gentofte Hospital  Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_12_2_1","DOI":"10.1097\/AOG.0000000000004522"},{"doi-asserted-by":"publisher","key":"e_1_2_12_3_1","DOI":"10.1111\/1471-0528.17058"},{"doi-asserted-by":"publisher","key":"e_1_2_12_4_1","DOI":"10.3322\/caac.21628"},{"doi-asserted-by":"publisher","key":"e_1_2_12_5_1","DOI":"10.1097\/LGT.0000000000000525"},{"unstructured":"GOV.UK.Cervical screening: programme overview.2021. Accessed December 15 2023.https:\/\/www.gov.uk\/guidance\/cervical\u2010screening\u2010programme\u2010overview","key":"e_1_2_12_6_1"},{"doi-asserted-by":"publisher","key":"e_1_2_12_7_1","DOI":"10.1002\/cam4.4420"},{"doi-asserted-by":"publisher","key":"e_1_2_12_8_1","DOI":"10.1111\/aogs.12960"},{"doi-asserted-by":"publisher","key":"e_1_2_12_9_1","DOI":"10.1111\/j.1471-0528.2008.01748.x"},{"doi-asserted-by":"publisher","key":"e_1_2_12_10_1","DOI":"10.2147\/PPA.S259095"},{"doi-asserted-by":"publisher","key":"e_1_2_12_11_1","DOI":"10.1177\/1403494810393563"},{"doi-asserted-by":"publisher","key":"e_1_2_12_12_1","DOI":"10.1111\/cyt.12451"},{"unstructured":"World Health Organization.WHO guidelines for treatment of cervical intraepithelial neoplasia 2\u20133 and adenocarcinoma in\u00a0situ: cryotherapy large loop excision of the transformation zone and cold knife conization.2014. Accessed May 26 2021.http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK206775\/","key":"e_1_2_12_13_1"},{"doi-asserted-by":"publisher","key":"e_1_2_12_14_1","DOI":"10.1016\/j.ygyno.2013.09.002"},{"doi-asserted-by":"publisher","key":"e_1_2_12_15_1","DOI":"10.1111\/1471-0528.17200"},{"doi-asserted-by":"publisher","key":"e_1_2_12_16_1","DOI":"10.1007\/s10147-017-1124-z"},{"key":"e_1_2_12_17_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2023-078140","article-title":"Short term complications of conisation and long term effects on fertility related outcomes in Denmark: register based nationwide cohort study","volume":"388","author":"Aagaard M","year":"2025","journal-title":"BMJ"},{"doi-asserted-by":"publisher","key":"e_1_2_12_18_1","DOI":"10.1097\/AOG.0b013e3182841594"},{"doi-asserted-by":"publisher","key":"e_1_2_12_19_1","DOI":"10.1371\/journal.pone.0131790"},{"doi-asserted-by":"publisher","key":"e_1_2_12_20_1","DOI":"10.1016\/j.jogc.2018.01.023"},{"key":"e_1_2_12_21_1","first-page":"76","article-title":"Complications of outpatient LLETZ procedures","volume":"49","author":"Dunn TS","year":"2004","journal-title":"J Reprod Med"},{"doi-asserted-by":"publisher","key":"e_1_2_12_22_1","DOI":"10.1002\/ijc.30623"},{"doi-asserted-by":"publisher","key":"e_1_2_12_23_1","DOI":"10.1002\/ijgo.12000"},{"doi-asserted-by":"publisher","key":"e_1_2_12_24_1","DOI":"10.1097\/GME.0000000000000488"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.15111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T17:02:42Z","timestamp":1747674162000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.15111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,7]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/aogs.15111"],"URL":"https:\/\/doi.org\/10.1111\/aogs.15111","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"type":"print","value":"0001-6349"},{"type":"electronic","value":"1600-0412"}],"subject":[],"published":{"date-parts":[[2025,4,7]]},"assertion":[{"value":"2024-12-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}