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In addition to metabolic disturbances, obesity contributes to chronic low\u2010grade inflammation. This study aims to investigate the relationship between maternal overweight, obesity, and excessive weight gain during pregnancy and high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP), an acute\u2010phase reactant of inflammation and infection in maternal serum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>The PRINCE (Prenatal Identification of Children's Health) study is a prospective longitudinal pregnancy cohort conducted at the University Medical Centre Hamburg\u2010Eppendorf in Germany. In this study, biosamples and metadata were collected from 2011 to 2023. Hs\u2010CRP levels were measured in each trimester among 582 healthy, low\u2010risk women. Participants were categorized into weight classes based on their body mass index. Weight gain during pregnancy was evaluated according to the recommendations of the Institute of Medicine. For statistical analysis, the Wilcoxon and Kruskal\u2013Wallis tests were employed for continuous variables, whereas the Mann\u2013Whitney test was used for binary groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hs\u2010CRP levels are significantly higher in overweight and obese pregnant women throughout their pregnancy. During the first trimester, hs\u2010CRP compared to those of normal\u2010weight individuals (mean 3.4\u2009mg\/L; 95% CI 3.1 to 3.7) showed a 1.7\u2010fold increase in overweight (mean 5.9\u2009mg\/L; 95% CI 5.0 to 6.7; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and a 2.7\u2010fold increase in obesity (mean 9.3\u2009mg\/L; 95% CI 7.6 to 11.0; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Excessive weight gain during pregnancy is more common among overweight women (67%) and is associated with 1.5\u2010fold heightened hs\u2010CRP levels in the third trimester (mean 5.6\u2009mg\/L; 95% CI 4.7 to 6.4), compared to overweight women who follow the recommended weight gain guidelines (mean 3.7\u2009mg\/L; 95% CI 2.9 to 4.4; <jats:italic>p<\/jats:italic>\u2009=\u20090.009).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overweight and obesity, along with excessive gestational weight gain in individuals with preexisting overweight status, correlate with elevated levels of hs\u2010CRP during pregnancy. This phenomenon indicates chronic low\u2010grade inflammation in adipose tissue.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.15135","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T07:24:09Z","timestamp":1746602649000},"page":"1339-1346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["High\u2010sensitivity CRP is elevated in pregnant women with overweight and obesity and modulated by gestational weight\u00a0gain"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3781-1363","authenticated-orcid":false,"given":"Ann\u2010Christin","family":"Tallarek","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Fetal Medicine University Medical Centre Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"Junior Research Center for Reproduction: Sexual and Reproductive Health in Overweight and Obesity (SRHOO) University Medical Center 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