{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:15:26Z","timestamp":1790374526905,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Vulvar cancer survivors are at risk of experiencing impaired health\u2010related quality of life and sexual functioning after treatment. However, studies on survivorship challenges, particularly several years after treatment, are scarce. Our aim was to assess health\u2010related quality of life in Norwegian vulvar cancer survivors more than 5\u2009years after treatment and to compare reported vulvar symptoms and sexual functioning with women from a normative sample of the general Norwegian female population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Patients treated primarily for early\u2010stage vulvar squamous cell carcinoma at the Norwegian Radium Hospital between 2006 and 2016 were invited to participate. Health\u2010related quality of life, vulvar symptoms, and sexual functioning were assessed using the EORTC QLQ\u2010C30 and EORTC QLQ\u2010VU34. To recruit a normative sample, the EORTC QLQ\u2010VU34 was also distributed to a sample of Norwegian women with no prior history of cancer. EORTC QLQ\u2010C30 scores among vulvar cancer survivors were compared to \u201cthresholds for clinical importance.\u201d EORTC QLQ\u2010VU34 scores among cancer survivors were compared to those of the normative sample.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 44 (57%) of 77 vulvar cancer survivors completed the questionnaires, and 334 women from the general population were included for the normative sample. A considerable proportion of cancer survivors reported clinically relevant problems: 43% reported impaired physical functioning, while 30% experienced impaired emotional, cognitive, and social functioning. Genital and groin symptoms were significantly more common among cancer survivors than among women in the normative sample. Fewer vulvar cancer survivors were sexually active (9\/44 (20%) versus 232\/334 (69%)) and they reported a higher degree of sexual dysfunction compared to the normative sample.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Vulvar cancer survivors reported impaired health\u2010related quality of life even several years after treatment. Vulvar complaints and impaired sexual functioning were more common among vulvar cancer survivors than among women from the normative sample.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.15155","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T09:24:22Z","timestamp":1747214662000},"page":"1505-1516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Long\u2010term quality of life, vulvar symptoms, and sexual functioning: A cross\u2010sectional study of Norwegian vulvar cancer survivors"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0578-4433","authenticated-orcid":false,"given":"Christin Julia","family":"Meltzer\u2010Gunnes","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Sorlandet Hospital HF  Kristiansand Norway"},{"name":"Faculty of Medicine, Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milada C.","family":"Hagen","sequence":"additional","affiliation":[{"name":"Department of Nursing and Health Promotion, Faculty of Health Sciences Oslo Metropolitan University  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9941-2130","authenticated-orcid":false,"given":"Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Norwegian Radium Hospital Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pernille T.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aarhus University Hospital  Aarhus Denmark"},{"name":"Faculty of Health, Institute of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Clinical Research, Faculty of Health Science University of Southern 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