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The aim was to investigate if offspring exposure to maternal Inflammatory bowel disorder (IBD), or specifically the IBD disorder Crohn's disease, during gestation is associated with neurodevelopmental or psychiatric disorders in childhood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>We conducted a population\u2010based registry study in Finland. All live births from 1996 until 2014 in Finland were included and followed up until December 2018. Exposure was maternal IBD or Crohn's disease. Outcome was a broad range of neurodevelopmental and psychiatric disorders in offspring. Cox proportional hazards regression was applied to assess association. Sensitivity analyses included assessing, for example, exposure to severe episode of IBD or Crohn's disease, the outcome psychotropic medication for the children, and influence from perinatal risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the participants (<jats:italic>N<\/jats:italic>\u2009=\u20091\u2009105\u2009997), 0.55% (<jats:italic>N<\/jats:italic>\u2009=\u20096067) were exposed to maternal IBD 0.18% (<jats:italic>N<\/jats:italic>\u2009=\u20091959) to maternal Crohn's disease. Among the children exposed to IBD or the subgroup Crohn's disease, 6.3% or 7.3%, respectively, had received an outcome diagnosis during the follow\u2010up. There were higher risks for Sleeping disorders HR\u2009=\u20091.77 (95% CI, 1.13\u20132.78), Other feeding disorders HR\u2009=\u20091.83 (95% CI, 1.19, 2.19), and Incontinence HR\u2009=\u20091.42 (95% CI, 1.02\u20131.97) in children exposed to maternal Crohn's disease compared to unexposed children. This was supported by even higher point risk estimates for Incontinence HR\u2009=\u20092.43 (95% CI, 1.34\u20134.38) and Other feeding disorders HR\u2009=\u20092.83 (95% CI, 1.35\u20135.91) in offspring where the mother was hospitalized for Crohn's disease during pregnancy. Furthermore, there was a higher risk of dispensed antipsychotic, anxiolytic, hypnotic, and\/or sedative medications for children with maternal Crohn's disease HR\u2009=\u20091.38 (95% CI, 1.03\u20131.85). These associations were not explained by cesarean section, preterm birth, or small birth size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Offspring exposed to maternal Crohn's disease during pregnancy had modestly higher risks of early sleeping, continence, and feeding disturbances. The exposure had no detectable association with any of the other psychiatric disorders studied.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.15167","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T11:19:49Z","timestamp":1749727189000},"page":"1463-1474","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Offspring exposure to Crohn's disease during pregnancy and association with milder psychiatric regulatory disturbances in childhood"],"prefix":"10.1111","volume":"104","author":[{"given":"Elin","family":"Skott","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet  Stockholm Sweden"},{"name":"Center for Molecular Medicine Karolinska University Hospital Solna  Stockholm Sweden"},{"name":"Prima V\u00e5rd AB  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustav","family":"S\u00f6derberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Psychiatry Faculty of Medicine, Lund University  Lund Sweden"},{"name":"Department of Gastroenterology and Nutrition Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MaiBritt","family":"Giacobini","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet  Stockholm Sweden"},{"name":"Center for Molecular Medicine Karolinska University Hospital Solna  Stockholm Sweden"},{"name":"Prima V\u00e5rd AB  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samson","family":"Nivins","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxia","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Nursing and Rehabilitation, Cheeloo College of Medicine Shandong University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Lindqvist","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Psychiatry Faculty of Medicine, Lund University  Lund Sweden"},{"name":"Department of Psychiatry Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Gissler","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet  Stockholm Sweden"},{"name":"Center for Molecular Medicine Karolinska University Hospital Solna  Stockholm Sweden"},{"name":"Department of Data and Analytics Finnish Institute for Health and Welfare  Helsinki 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