{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:02:53Z","timestamp":1756512173903,"version":"3.44.0"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020989","name":"Gedeon Richter France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020989","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Uterine damage after pelvic radiotherapy or total\u2010body irradiation is well described, with decreased uterine volume and high obstetrical morbidity. Some recent studies have reported a smaller uterus in child, adolescent, and young adult cancer survivors treated with chemotherapy only. This systematic review investigated the long\u2010term effects of gonadotoxic therapy on uterine volume during childhood, adolescence, and young adulthood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Data sources were Medline, Embase, and the Cochrane Library databases from 1990 to April 2023 searched using the following search terms: cancer survivors, bone marrow transplantation, chemotherapy, radiotherapy, and uterine volume. Study selection and synthesis: Only comparative studies reporting uterine volume in adult women who had received chemotherapy and\/or radiotherapy during childhood, adolescence, or young adulthood (&lt;25\u2009years) were included. Two independent reviewers performed study selection, bias assessment using the ROBINS\u2010I tool, and data extraction. The main outcome was uterine volume (mL). A Bayesian network meta\u2010analysis with meta\u2010regression for parity and serious risk of bias was performed using a random\u2010effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After reviewing 2847 abstracts, four studies were selected for the meta\u2010analysis. Uterine volume data were available for 225 women after chemotherapy, 153 women after chemoradiotherapy, and 257 control women without cancer. Uterine volume was significantly lower in the chemoradiotherapy group than in the control group (\u221229.2\u2009mL [\u221249.1, \u221212.5]). Uterine volume was significantly decreased in the chemoradiotherapy group compared to the chemotherapy group (\u221220.9\u2009mL [\u221239.1, \u22120.3]). The difference in the mean uterine volume between the control and chemotherapy groups was 8.2\u2009mL [\u221211.8, 34.2] and was not significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our meta\u2010analysis confirms the well\u2010known data on chemoradiotherapy\u2010induced uterine damage. Although some studies have suggested the potential impact of high doses of chemotherapy on uterine volume, this meta\u2010analysis did not find any significant decrease in uterine volume after chemotherapy. This result could help counsel age\u2010reproductive women and physicians who perform assisted reproductive technologies in long\u2010term CAYA Cancer survivors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.70003","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T02:30:04Z","timestamp":1750818604000},"page":"1616-1626","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Uterine volume assay after gonadotoxic therapies in childhood, adolescence, and young adulthood: A systematic review and Bayesian network meta\u2010analysis"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8083-1346","authenticated-orcid":false,"given":"Elo\u00efse","family":"Fraison","sequence":"first","affiliation":[{"name":"Department of Gynecology\u2010Obstetric and Reproductive Medicine University Hospital of Lyon  Lyon France"},{"name":"UMR, CNRS 5558, Laboratory of Biometry and Evolutionary Biology (LBBE)  Villeurbanne France"},{"name":"Claude Bernard University  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Huberlant","sequence":"additional","affiliation":[{"name":"Department of Gynaecology\u2010Obstetric and Reproductive Medicine University Hospital of Nimes  N\u00eemes France"},{"name":"IBMM, CNRS, ENSCM, Polymers for Health and Biomaterials University of Montpellier  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathilde","family":"Cavalieri","sequence":"additional","affiliation":[{"name":"Department of Gynecology\u2010Obstetric and Reproductive Medicine University Hospital Fran\u00e7ois Mitterrand  Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurore","family":"Gueniffey","sequence":"additional","affiliation":[{"name":"Clinique Belledonne  Saint\u2010Martin\u2010d'H\u00e8res France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justine","family":"Riss","sequence":"additional","affiliation":[{"name":"Department of Gynecology\u2010Obstetric and Reproductive Medicine University Hospital of Strasbourg  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Rousset\u2010Jablonski","sequence":"additional","affiliation":[{"name":"Oncology and Surgery Department Centre L\u00e9on B\u00e9rard  Lyon France"},{"name":"Department of Gynecology\u2010Obstetric H\u00f4pital Femme M\u00e8re Enfant  Bron France"},{"name":"EA 7425 HESPER\u2010 Health Services and Performance Research University of Lyon  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blandine","family":"Courbiere","sequence":"additional","affiliation":[{"name":"Department of Gynecology\u2010Obstetric and Reproductive Medicine AP\u2010HM, H\u00f4pital La Conception  Marseille France"},{"name":"IMBE, Aix\u2010Marseille Univ, Avignon Univ, CNRS, IRD  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmz041"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.10.016"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.10.043"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2022.12.040"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem027"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0283940"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280219889080"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/09622802211047348"},{"key":"e_1_2_12_12_1","unstructured":"Chapter\u00a011: undertaking network meta\u2010analyses."},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1214\/ss\/1177011136"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.03.016"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v106.i02"},{"key":"e_1_2_12_16_1","unstructured":"SeoM SchmidC.bnma: Bayesian network meta\u2010analysis using \u2018JAGS\u2019.2024. R package version 1.6.0https:\/\/CRAN.R\u2010project.org\/package=bnma"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0412.2004.00332.x"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(24)00269-9"},{"issue":"1","key":"e_1_2_12_19_1","article-title":"Reduced uterine volume after children, adolescent, and young adult chemotherapy exposure. A systematic review and Bayesian network meta\u2010analysis","volume":"39","author":"Courbiere B","year":"2024","journal-title":"Hum Reprod"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.70003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T02:04:39Z","timestamp":1756433079000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.70003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,24]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/aogs.70003"],"URL":"https:\/\/doi.org\/10.1111\/aogs.70003","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"type":"print","value":"0001-6349"},{"type":"electronic","value":"1600-0412"}],"subject":[],"published":{"date-parts":[[2025,6,24]]},"assertion":[{"value":"2024-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}