{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T10:47:57Z","timestamp":1767005277249,"version":"3.48.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI22\/00462"],"award-info":[{"award-number":["PI22\/00462"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018689","name":"Spanish Clinical Research Network","doi-asserted-by":"publisher","award":["PT13\/0002\/0028"],"award-info":[{"award-number":["PT13\/0002\/0028"]}],"id":[{"id":"10.13039\/501100018689","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Preeclampsia and fetal growth restriction, which are clinical presentations of placental dysfunction, are frequently associated with angiogenic imbalance during pregnancy and increased long\u2010term cardiovascular risk. Whether this risk is driven by the pre\u2010pregnancy risk factors, clinical disease, or by an elevated sFlt\u20101\/PlGF ratio remains unclear. This study aimed to assess the association between vascular assessments (ophthalmic artery Doppler and carotid intima\u2010media thickness) 3\u20136\u2009years postpartum and a history of preeclampsia and fetal growth restriction, and to evaluate if associations were impacted by an angiogenic imbalance during pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>This was a cross\u2010sectional study, which included individuals prospectively recruited during their index pregnancy between 2018 and 2021 and re\u2010evaluated 3\u20136\u2009years postpartum. Preeclampsia, fetal growth restriction, and sFlt\u20101\/PlGF values were defined from pregnancy data. Postpartum assessment included ophthalmic artery Doppler and carotid intima\u2010media thickness performed by a single operator. Multivariable linear regression models assessed associations between placental dysfunction, angiogenic imbalance, and vascular parameters, adjusting for maternal covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      354 participants were included, 148 with and 206 without a history of preeclampsia or fetal growth restriction. Both placental dysfunction and angiogenic imbalance during pregnancy were independently associated with a significantly higher ophthalmic artery peak systolic velocity ratio 3\u20136\u2009years postpartum. Participants with a history of placental dysfunction showed higher values compared to those without [0.75 (0.67\u20130.81) vs. 0.69 (0.63\u20130.78),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03], as did those with an elevated sFlt\u20101\/PlGF ratio during pregnancy [0.76 (0.66\u20130.82) vs. 0.70 (0.64\u20130.78),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03]. The highest values were observed in women who had experienced both conditions. When preeclampsia and fetal growth restriction were analyzed separately, the association remained significant for preeclampsia, whereas in the fetal growth restriction group, a significant difference was observed only in the right eye. No statistically significant differences were observed in carotid intima\u2010media thickness.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both a history of angiogenic imbalance and a clinical placental dysfunction presentation (particularly preeclampsia) during pregnancy were associated with increased ophthalmic artery peak systolic velocity ratio 3\u20136\u2009years postpartum, whereas carotid intima\u2010media thickness did not differ between the study groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.70059","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:16:45Z","timestamp":1761070605000},"page":"94-104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ophthalmic artery Doppler and carotid intima\u2010media thickness 3\u20136\u2009years postpartum in women with and without a history of placental insufficiency"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2415-1626","authenticated-orcid":false,"given":"Pablo","family":"Garcia\u2010Manau","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal\u2010Fetal Medicine Unit, Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Nephrology Research Group Institut de Recerca (IR SANT PAU)  Barcelona Spain"},{"name":"Departament de Pediatria, Obstetr\u00edcia i Ginecologia i de Medicina Preventiva i Salut P\u00fablica Universitat Aut\u00f2noma de Barcelona  Bellaterra Spain"},{"name":"Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin Network (RICORS\u2010SAMID, RD21\/0012\/0019) Instituto de Salud Carlos III  Madrid 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Child Chronic Diseases of Perinatal and Developmental Origin Network (RICORS\u2010SAMID, RD21\/0012\/0001) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoraida","family":"Garcia","sequence":"additional","affiliation":[{"name":"Women and Perinatal Health Research Group Institut de Recerca (IR SANT PAU)  Barcelona Spain"},{"name":"Spanish Network in Maternal, Neonatal, Child and Developmental Health Research (RICORS\u2010SAMID, RD24\/0013\/0001) and Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin Network (RICORS\u2010SAMID, RD21\/0012\/0001) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2180-1715","authenticated-orcid":false,"given":"Carmen","family":"Garrido\u2010Gim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal\u2010Fetal Medicine Unit, Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Departament de Pediatria, Obstetr\u00edcia i Ginecologia i de Medicina Preventiva i Salut P\u00fablica Universitat Aut\u00f2noma de Barcelona  Bellaterra Spain"},{"name":"Women and Perinatal Health Research Group Institut de Recerca (IR SANT PAU)  Barcelona Spain"},{"name":"Spanish Network in Maternal, Neonatal, Child and Developmental Health Research (RICORS\u2010SAMID, RD24\/0013\/0001) and Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin Network (RICORS\u2010SAMID, RD21\/0012\/0001) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Pellicer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal\u2010Fetal Medicine Unit, Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johana","family":"Ullmo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal\u2010Fetal Medicine Unit, Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Departament de Pediatria, Obstetr\u00edcia i Ginecologia i de Medicina Preventiva i Salut P\u00fablica Universitat Aut\u00f2noma de Barcelona  Bellaterra Spain"},{"name":"Women and Perinatal Health Research Group Institut de Recerca (IR SANT PAU)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madalina","family":"Nan","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Hospital de la Santa Creu i Sant Pau Institut d'Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB Sant Pau)  Barcelona Spain"},{"name":"Department of Biochemistry and Molecular Biology, Facultat de Medicina Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josefina","family":"Mora","sequence":"additional","affiliation":[{"name":"Spanish Network in Maternal, Neonatal, Child and Developmental Health Research (RICORS\u2010SAMID, RD24\/0013\/0001) and Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin Network (RICORS\u2010SAMID, RD21\/0012\/0001) Instituto de Salud Carlos III  Madrid Spain"},{"name":"Department of Clinical Biochemistry, Hospital de la Santa Creu i Sant Pau Institut d'Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB Sant Pau)  Barcelona Spain"},{"name":"Department of Biochemistry and Molecular Biology, Facultat de Medicina Universitat Aut\u00f2noma de Barcelona  Barcelona 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de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariona","family":"Jordi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal\u2010Fetal Medicine Unit, Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Choliz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal\u2010Fetal Medicine Unit, Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nica","family":"Cruz\u2010Lemini","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal\u2010Fetal Medicine Unit, Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Departament de 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