{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T01:52:53Z","timestamp":1773021173863,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Specific fetal heart rate (FHR) patterns are associated with fetal compromise. Several placental histopathological findings are associated with neonatal morbidity and adverse neurodevelopment. The relationships between intrapartum FHR patterns and placental histopathology in infants with hypoxic\u2013ischemic encephalopathy (HIE) remain uncertain. This study hypothesized that in infants with HIE, placental histopathology findings are related to abnormal FHR patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>This was an observational study performed on a historical cohort from a single tertiary neonatal intensive care unit. Infants were born at \u226536\u2009weeks' gestation with moderate or severe HIE between September 2006 and December 2021. Placental histopathology was assessed by a perinatal pathologist using the Amsterdam Working Group Criteria. FHR, recorded from intrapartum cardiotocography (CTG) was assessed by an obstetrician using a structured proforma. Assessors were blinded to clinical course and outcomes. Duration and type of FHR abnormality were compared across categories of placental histopathology findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty infants with moderate or severe HIE (with complete data relating to intrapartum CTG and placental histopathology) were included. Increased duration of FHR abnormality was associated with the presence of histological chorioamnionitis (HCA) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013) but not with other placental histopathological lesions. There was no evidence of associations between placental histopathology findings and specific FHR features on intrapartum CTG.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrates an association between HCA and increased duration of CTG abnormality in infants with moderate or severe HIE. Intrapartum CTG alone is limited in its ability to identify the presence or absence of placental histopathology. Multimodal intrapartum assessment, such as CTG with placental NIRs or Doppler assessment, may improve the maternal\u2013placental\u2013fetal triad assessment. This could lead to improved intrapartum risk stratification and infant outcomes. Future research should investigate the utility of multimodal assessment to improve risk stratification in labor.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.70064","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:32:18Z","timestamp":1760556738000},"page":"2254-2262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Placental pathology and its association with duration of abnormal fetal heart tracing in near\u2010term and term infants with hypoxic\u2013ischemic encephalopathy: A retrospective study"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0851-5378","authenticated-orcid":false,"given":"\u00c1ine","family":"Fox","sequence":"first","affiliation":[{"name":"Royal College of Surgeons (RCSI)  Dublin Ireland"},{"name":"Department of Neonatology Rotunda Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Doyle","sequence":"additional","affiliation":[{"name":"Department of Histopathology Rotunda Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7033-241X","authenticated-orcid":false,"given":"Adam","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Belfast Health and Social Care Trust  Belfast UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Farren","sequence":"additional","affiliation":[{"name":"Department of Obstetrics The Coombe Hospital  Dublin Ireland"},{"name":"Department of Obstetrics Rotunda Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocco","family":"Cuzzilla","sequence":"additional","affiliation":[{"name":"Royal College of Surgeons (RCSI)  Dublin Ireland"},{"name":"Neonatal Services and Newborn Research The Royal Women's Hospital  Melbourne Victoria Australia"},{"name":"Department of Obstetrics, Gynaecology and Newborn Health The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Geary","sequence":"additional","affiliation":[{"name":"Royal College of Surgeons (RCSI)  Dublin Ireland"},{"name":"Department of Obstetrics Rotunda Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Breda","family":"Hayes","sequence":"additional","affiliation":[{"name":"Royal College of Surgeons (RCSI)  Dublin Ireland"},{"name":"Department of Neonatology Rotunda Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire M.","family":"McCarthy","sequence":"additional","affiliation":[{"name":"University College Cork  Cork Ireland"},{"name":"Department of Obstetrics Cork University Maternity Hospital  Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.14301"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2024.04.001"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2024.101549"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/9781316161715.007"},{"key":"e_1_2_14_6_1","article-title":"Continuous cardiotocography (CTG) as a form of electronic fetal monitoring (EFM) for fetal assessment during labour","volume":"2","author":"Alfirevic Z","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-025-05652-2"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.09.072"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1023821"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/10935266231178615"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500100030012"},{"key":"e_1_2_14_12_1","volume-title":"National Clinical Practice Guideline: Fetal Heart Rate Monitoring","author":"Rowland MTJ","year":"2025"},{"key":"e_1_2_14_13_1","unstructured":"Excellence NNIfHaC.Fetal monitoring during labour.2022."},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0225-CC"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2011.03.006"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2025.04.073"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2010.02.003"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.06.002"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.11.062"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2001.006"},{"issue":"3","key":"e_1_2_14_21_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2024-084578","article-title":"Detecting and responding to deterioration of a baby during labour: surveys of maternity professionals to inform co\u2010design and implementation of a new standardised approach","volume":"15","author":"Scheer JW","year":"2025","journal-title":"BMJ Open"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2021.03.014"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44294-024-00015-1"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4828"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-199402000-00006"},{"issue":"6","key":"e_1_2_14_26_1","article-title":"Prelabor and intrapartum Doppler ultrasound to predict fetal compromise","volume":"3","author":"Dall'Asta A","year":"2021","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-021-00946-6"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000520987"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0231461"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.424969"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.70064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T01:47:11Z","timestamp":1764640031000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.70064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,15]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/aogs.70064"],"URL":"https:\/\/doi.org\/10.1111\/aogs.70064","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,15]]},"assertion":[{"value":"2025-09-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}