{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:33:34Z","timestamp":1791380014349,"version":"4.3.3"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007403","name":"Dagmar Marshalls Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007403","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Adequate treatment of cervical precancer, defined as negative margins and a negative HPV test post\u2010treatment, is essential for cervical cancer prevention, as inadequate excision of cervical precancer and a positive HPV test are associated with increased risk of recurrence. Here, we aimed to describe trends in the proportion of women receiving adequate treatment in Denmark.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Nationwide historical cohort study including Danish women \u226518\u2009years treated with large loop excision of the transformation zone (LLETZ) from 2013 to 2022. Using the Danish Pathology Register, we collected information on all LLETZ procedures performed due to cervical intraepithelial neoplasia grade 1 or worse (CIN1+). We calculated the proportion of negative margins and negative HPV tests post\u2010treatment, overall and stratified by histology, age, calendar time, and residing region. Results were mainly reported descriptively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 41\u2009128 women (median age: 35\u2009years, interquartile range: 28\u201344). A total of 20\u2009744 (50.4%) had negative margins, with the lowest proportion in women with CIN3 (47.2%) or adenocarcinoma in\u00a0situ (38.3%). The proportion of negative margins declined with increasing age, from 54.1% in women aged 18\u201329\u2009years to 43.6% in women aged \u226550\u2009years. Overall, 62.4% had a negative HPV test, with no major differences observed across histology groups. The proportion of negative HPV tests ranged from 62.8% to 66.9% in women aged 18\u201349, whereas it was lower in women aged \u226550\u2009years (48.4%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Women aged \u226550\u2009years were less likely to have negative margins and a negative HPV test post\u2010treatment compared to women aged 18\u201349. These findings prompt a need to optimize treatment in this group of women to reduce the risk of cervical cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.70107","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T11:42:03Z","timestamp":1764070923000},"page":"186-194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Negative margins and negative\n                    <scp>HPV<\/scp>\n                    tests after large loop excision of the transformation zone: A nationwide historical cohort study"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0741-5968","authenticated-orcid":false,"given":"Ane\u2010Kersti Skaarup","family":"Knudsen","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, G\u00f8dstrup Hospital University Clinic for HPV\u2010Related Gynecological Disease  Herning Denmark"},{"name":"NIDO | Centre for Research &amp; Education G\u00f8dstrup Hospital  Herning Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5384-2557","authenticated-orcid":false,"given":"Tina Hovgaard","family":"Randrup","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, G\u00f8dstrup Hospital University Clinic for HPV\u2010Related Gynecological Disease  Herning Denmark"},{"name":"NIDO | Centre for Research &amp; Education G\u00f8dstrup Hospital  Herning Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3868-106X","authenticated-orcid":false,"given":"Ulrik Schi\u00f8ler","family":"Kesmodel","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Obstetrics &amp; Gynecology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9134-804X","authenticated-orcid":false,"given":"Berit Bargum","family":"Booth","sequence":"additional","affiliation":[{"name":"The Research Unit of Obstetrics &amp; Gynecology Odense University Hospital  Odense Denmark"},{"name":"Department of Obstetrics &amp; Gynecology Randers Regional Hospital  Randers Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4149-4708","authenticated-orcid":false,"given":"Line Winther","family":"Gustafson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Public Health Programmes, Randers Regional Hospital University Research Clinic for Cancer Screening  Randers Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6583-3319","authenticated-orcid":false,"given":"Therese Koops","family":"Gr\u00f8nborg","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University and Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4616-9827","authenticated-orcid":false,"given":"Anne","family":"Hammer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, G\u00f8dstrup Hospital University Clinic for HPV\u2010Related Gynecological Disease  Herning Denmark"},{"name":"NIDO | Centre for Research &amp; Education G\u00f8dstrup Hospital  Herning Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"e_1_2_14_2_1","unstructured":"World Health Organization Cervical Cancer Elimination. 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