{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T18:29:57Z","timestamp":1773253797316,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100031015","name":"Hospital Cl\u00ednic de Barcelona","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI15\/00263"],"award-info":[{"award-number":["PI15\/00263"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/00675"],"award-info":[{"award-number":["PI17\/00675"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/00246"],"award-info":[{"award-number":["PI20\/00246"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI24\/00127"],"award-info":[{"award-number":["PI24\/00127"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["INT21\/00027"],"award-info":[{"award-number":["INT21\/00027"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008666","name":"Fundaci\u00f3 la Marat\u00f3 de TV3","doi-asserted-by":"publisher","award":["202016\u201030\u201031"],"award-info":[{"award-number":["202016\u201030\u201031"]}],"id":[{"id":"10.13039\/100008666","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008666","name":"Fundaci\u00f3 la Marat\u00f3 de TV3","doi-asserted-by":"publisher","award":["202415\u201030\u201031"],"award-info":[{"award-number":["202415\u201030\u201031"]}],"id":[{"id":"10.13039\/100008666","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008666","name":"Fundaci\u00f3 la Marat\u00f3 de TV3","doi-asserted-by":"publisher","award":["82\/257"],"award-info":[{"award-number":["82\/257"]}],"id":[{"id":"10.13039\/100008666","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100025246","name":"Departament de Recerca i Universitats, Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2021\u2010SGR\u201001422"],"award-info":[{"award-number":["2021\u2010SGR\u201001422"]}],"id":[{"id":"10.13039\/501100025246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Tetralogy of Fallot (ToF) shows variability in neonatal outcomes, and identifying reliable prenatal predictors is essential for optimizing perinatal management. The aim of this study was to determine the prognostic value of feto\u2010placental data and prenatal echocardiography in the third trimester in ToF and to compare these findings with a matched control population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Multicenter prospective cohort study (2011\u20132023) at two referral centers (BCNatal and University Hospital of Gie\u00dfen and Marburg). The cohort included 63 fetuses with isolated ToF and 66 healthy controls. All fetuses underwent a third trimester ultrasound and comprehensive echocardiography with 2D speckle tracking. Severe small\u2010for\u2010gestational age (SGA) was defined as estimated fetal weight (EFW) below the third percentile. Adverse composite outcomes were defined as the need for prostaglandin infusion, surgery or ductal stenting, corrective surgery before 3\u2009months, and\/or neonatal intensive care unit stay \u22657\u2009days. The association of feto\u2010placental and cardiac data with adverse composite outcome was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with controls, ToF fetuses showed higher rates of severe SGA (19% vs. 0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Cardiac findings showed mild biventricular concentric hypertrophy (relative wall thickness ToF 0.7 [0.5\u20130.9] vs. controls 0.5 [0.5\u20130.6],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), and reduced deformation (right and left ventricular global longitudinal strain: ToF \u201017.3%\u2009\u00b1\u20093.8 vs. controls \u221219.3%\u2009\u00b1\u20093.1,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001; ToF \u201018.0%\u2009\u00b1\u20093.8 vs. controls \u221220.9%\u2009\u00b1\u20093.45,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), regardless of placental dysfunction. The adverse composite outcome occurred in 29.3% of ToF cases with pulmonary stenosis. Within this group, EFW &lt;3rd centile (adjusted OR 9.17) and PV peak systolic velocity (aOR 1.03) showed the strongest association with adverse outcomes. Their combined performance yielded an AUC of 0.734, with a predictive value of 71.4% at a 20% false\u2010positive rate. Assessed individually, the AUC was 0.650 for PV peak systolic velocity and 0.639 for estimated fetal weight. Optimal PV Doppler cutoff values were &gt;70\u2009cm\/s when EFW was &lt;3rd centile, and &gt;144\u2009cm\/s when EFW was above the 3rd centile.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Combining EFW with PV artery Doppler may allow identification of a high\u2010risk subgroup of ToF\u2010PS fetuses who may benefit from closer prenatal monitoring and prompt neonatal care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.70137","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T17:42:26Z","timestamp":1769622146000},"page":"479-491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic value of fetal growth and prenatal functional echocardiography in tetralogy of FALLOT"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6938-9104","authenticated-orcid":false,"given":"Laura","family":"Nogu\u00e9","sequence":"first","affiliation":[{"name":"BCNatal Fetal Medicine Research Center (Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u) University of Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August pi i Sunyer (IDIBAPS)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar","family":"Bennasar","sequence":"additional","affiliation":[{"name":"BCNatal Fetal Medicine Research Center (Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u) University of Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August pi i Sunyer (IDIBAPS)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Guirado","sequence":"additional","affiliation":[{"name":"BCNatal Fetal Medicine Research Center (Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u) University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Z\u00f6lner","sequence":"additional","affiliation":[{"name":"Division of Perinatal Medicine and Fetal Therapy Universit\u00e4tsklinikum Gie\u00dfen and Marburg  Gie\u00dfen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justus","family":"Reitz","sequence":"additional","affiliation":[{"name":"Division of Perinatal Medicine and Fetal Therapy Universit\u00e4tsklinikum Gie\u00dfen and Marburg  Gie\u00dfen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Axt\u2010Fliedner","sequence":"additional","affiliation":[{"name":"Division of Perinatal Medicine and Fetal Therapy Universit\u00e4tsklinikum Gie\u00dfen and Marburg  Gie\u00dfen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda C.","family":"Escobar\u2010D\u00edaz","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Department Sant Joan de D\u00e9u Hospital, Esplugues de Llobregat  Barcelona Spain"},{"name":"Cardiovascular Research Group Sant Joan de Deu Research Institute, Esplugues de Llobregat  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep Maria","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"BCNatal Fetal Medicine Research Center (Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u) University of Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August pi i Sunyer (IDIBAPS)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduard","family":"Gratac\u00f3s","sequence":"additional","affiliation":[{"name":"BCNatal Fetal Medicine Research Center (Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u) University of Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e0tima","family":"Crispi","sequence":"additional","affiliation":[{"name":"BCNatal Fetal Medicine Research Center (Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u) University of Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"BCNatal Fetal Medicine Research Center (Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u) University of Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August pi i Sunyer (IDIBAPS)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the BCNatal and Gie\u00dfen and Marburg University investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.025"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12947-022-00274-5"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5697"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2844"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12120"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-013-0857-3"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0753-0008"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11196"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6796"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.15486"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1151814"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2019.1632285"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2009.07.029"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.06.005"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.10.033"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.676994"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17093056"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17164"},{"issue":"5","key":"e_1_2_14_20_1","first-page":"80","article-title":"Preeclampsia and fetal congenital heart defects","volume":"18","author":"Ferreira BD","year":"2022","journal-title":"Curr Cardiol Rev"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12252"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.07.025"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17365"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht389"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8831"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12403"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(87)90365-6"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1979.tb10804.x"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2006.12.015"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.15.08060"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5166"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.14454"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.21876"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.14811"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19048"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.14799"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11051414"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.021793"},{"issue":"20","key":"e_1_2_14_40_1","first-page":"3271","article-title":"Placenta\u2010related complications in women carrying a foetus with congenital heart disease","volume":"29","author":"Ruiz A","year":"2016","journal-title":"J Matern Fetal Neonatal Med"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2022.12.006"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.29250"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.15.08017"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.764676"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15987"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00235.2018"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36458-1"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1273413"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-020-00662-8"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.76.3.280"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1098248"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.70137","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aogs.70137","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.70137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:24:11Z","timestamp":1773188651000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.70137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,28]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/aogs.70137"],"URL":"https:\/\/doi.org\/10.1111\/aogs.70137","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,28]]},"assertion":[{"value":"2025-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}