{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:56:47Z","timestamp":1792205807014,"version":"4.4.0"},"reference-count":100,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Recurrent implantation failure (RIF) is a multifactorial reproductive disorder, often associated with chronic endometritis (CE) and alterations of the intrauterine microbiota.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>This systematic review evaluated whether microbiota\u2010targeted therapeutic interventions improve pregnancy outcomes in women with CE\u2010associated RIF undergoing in\u00a0vitro fertilization (IVF)\u2010embryo transfer (ET). Study quality and risk of bias were assessed using the Newcastle\u2010Ottawa Scale (NOS) and the Revised Cochrane Risk of Bias in Non\u2010Randomized Studies \u2013 of Interventions (ROBINS\u2010I).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four studies met the inclusion criteria, encompassing antibiotic, probiotic, and nutraceutical interventions. Considerable heterogeneity was observed in study design, diagnostic criteria, and microbiota assessment methods. Across studies, the reproductive outcomes revealed a clinical pregnancy rate of 50.5% (187\/370), ongoing pregnancy rate of 40.1% (107\/267), and live birth rate of 41.2% (105\/255). Other reported outcomes included seven multiple pregnancies (8.3%), 39 miscarriages (20.0%), 35 biochemical pregnancies (17.9%), and one stillbirth (1.17%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Microbiota\u2010targeted treatments may improve reproductive outcomes in women with CE\u2010associated RIF; however, the limited number of available studies, small sample sizes, and methodological variability reduce the strength of current evidence. High\u2010quality, prospective, confounder\u2010adjusted trials with rigorous participant selection processes and standardized, validated diagnostic and implementation criteria are needed to confirm these findings and inform clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.70138","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:56:17Z","timestamp":1770972977000},"page":"418-435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Endometrial microbiota\u2010targeted therapies for chronic endometritis\u2010associated recurrent implantation failure and their impact on\n                    <scp>IVF<\/scp>\n                    outcomes: A systematic review and methodological quality assessment"],"prefix":"10.1111","volume":"105","author":[{"given":"Bogdan","family":"Doroftei","sequence":"first","affiliation":[{"name":"Department of Mother and Child, Faculty of Medicine \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy  Iasi Romania"},{"name":"\u201cCuza Voda\u201d Clinical Hospital of Obstetrics and Gynecology  Iasi Romania"},{"name":"Origyn Fertility Center  Iasi Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4023-1765","authenticated-orcid":false,"given":"Ovidiu\u2010Dumitru","family":"Ilie","sequence":"additional","affiliation":[{"name":"Department of Mother and Child, Faculty of Medicine \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy  Iasi Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u2010Maria","family":"Dabuleanu (Cretu)","sequence":"additional","affiliation":[{"name":"Department of Mother and Child, Faculty of Medicine \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy  Iasi Romania"},{"name":"\u201cCuza Voda\u201d Clinical Hospital of Obstetrics and Gynecology  Iasi Romania"},{"name":"Origyn Fertility Center  Iasi Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iulia","family":"Selaru","sequence":"additional","affiliation":[{"name":"\u201cCuza Voda\u201d Clinical Hospital of Obstetrics and Gynecology  Iasi Romania"},{"name":"Origyn Fertility Center  Iasi Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Lunguleac","sequence":"additional","affiliation":[{"name":"Department of Mother and Child, Faculty of Medicine \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy  Iasi Romania"},{"name":"\u201cCuza Voda\u201d Clinical Hospital of Obstetrics and Gynecology  Iasi Romania"},{"name":"Origyn Fertility Center  Iasi Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Doroftei","sequence":"additional","affiliation":[{"name":"Faculty of Medicine \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy  Iasi Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciprian","family":"Ilea","sequence":"additional","affiliation":[{"name":"Department of Mother and Child, Faculty of Medicine \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy  Iasi Romania"},{"name":"\u201cCuza Voda\u201d Clinical Hospital of Obstetrics and Gynecology  Iasi Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2022.05.019"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex234"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.09.009"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmv016"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoac051"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2023.01.013"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa242"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoad023"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2012.05.017"},{"key":"e_1_2_12_11_1","unstructured":"Blanco\u2010BreindelMF SinghM KahnJ.Endometrial receptivity. In Treasure Island (FL)2025."},{"issue":"4","key":"e_1_2_12_12_1","first-page":"241","article-title":"Add\u2010ons in IVF programme\u2014hype or Hope?","volume":"7","author":"Datta AK","year":"2015","journal-title":"Facts Views Vis Obgyn"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex004"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.10.011"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.12.131"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu292"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.09.025"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12719"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.01.022"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.12.007"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.04.012"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.02.012"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.12.010"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.748447"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.01.006"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.03.017"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13937"},{"issue":"3","key":"e_1_2_12_28_1","first-page":"538","article-title":"Endometritis\u2014Diagnosis,Treatment and its impact on fertility\u2014A scoping review","volume":"26","author":"Singh N","year":"2022","journal-title":"JBRA Assist Reprod"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12782"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.15060"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10184063"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010485"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.09.075"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-021-01184-w"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12389"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4893437"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00901-0"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmy048"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20143405"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12941-023-00556-4"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.05.015"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-021-01877-1"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-9492LSF"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1307"},{"key":"e_1_2_12_46_1","article-title":"Comparing bibliometric analysis using PubMed, Scopus, and web of science databases","volume":"152","author":"AlRyalat SAS","year":"2019","journal-title":"J Vis Exp"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1729"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2014.10.008"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.2196\/jmir.2624"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11192-020-03690-4"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-1842.2012.00992.x"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12583"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11192-022-04289-7"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-021-01583-y"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-024-02320-4"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1736"},{"key":"e_1_2_12_57_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.5","author":"Li T","year":"2024"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_12_59_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.5","author":"Higgins JP","year":"2024"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1411"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-022-06755-2"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-022-02688-6"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-022-02528-7"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12941-024-00710-6"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880405"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des323"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.03.004"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-021-01239-y"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202300110"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3935"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0029-9"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deab009"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2021.05.045"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa372"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-92906-9"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12040878"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14212"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12105"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33428"},{"key":"e_1_2_12_81_1","article-title":"Dynamics of microbiome changes in the endometrium and uterine cervix during embryo implantation: A comparative analysis","volume":"29","author":"Bednarska\u2010Czerwi\u0144ska A","year":"2023","journal-title":"Med Sci Monit Int Med J Exp Clin Res"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11123348"},{"issue":"9","key":"e_1_2_12_83_1","article-title":"Chronic endometritis and uterine endometrium microbiota in recurrent implantation failure and recurrent pregnancy loss","volume":"11","author":"Takimoto K","year":"2023","journal-title":"Biomedicine"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719113508817"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1086\/598686"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1002611107"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00081"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.03242-19"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dez065"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2020.08.015"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.14297"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.10.019"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmy012"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-020-01955-8"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12754"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010180"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.03.074"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.09.061"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.06.044"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-018-1482-y"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032995"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.70138","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aogs.70138","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.70138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:24:19Z","timestamp":1773188659000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.70138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,13]]},"references-count":100,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/aogs.70138"],"URL":"https:\/\/doi.org\/10.1111\/aogs.70138","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,13]]},"assertion":[{"value":"2025-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}